Sökning: onr:"swepub:oai:DiVA.org:umu-191071" >
Pretreatment With P...
Pretreatment With P2Y12 Inhibitors in Patients With Chronic Coronary Syndrome Undergoing Percutaneous Coronary Intervention : A Report From the Swedish Coronary Angiography and Angioplasty Registry
-
- Jurga, Juliane (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
-
- Szummer, Karolina Elizabeth (författare)
- Department of Cardiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Huddinge, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
-
- Lewinter, Christian (författare)
- Department of Cardiology, Karolinska Institutet and Karolinska University Hospital, C.L., L.M., Stockholm, Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
-
visa fler...
-
- Mellbin, Linda (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
-
- Götberg, Matthias (författare)
- Department of Cardiology, Lund University Hospital, Skåne, Sweden,Lund Univ Hosp, Sweden
-
- Zwackman, Sammy (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
-
- Nilsson, Johan (författare)
- Umeå universitet,Kardiologi,Department of Cardiology, Umeå University and Umeå University Hospital,Umea Univ, Sweden; Umea Univ Hosp, Sweden
-
- Völz, Sebastian, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
- Erlinge, David (författare)
- Department of Cardiology, Lund University Hospital, Skåne, Sweden,Lund Univ Hosp, Sweden
-
- Persson, Jonas (författare)
- Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden,Danderyd Hosp, Sweden
-
- Omerovic, Elmir, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
-
- Jernberg, Tomas (författare)
- Karolinska Institutet,Danderyd Hosp, Sweden
-
- Venetsanos, Dimitrios (författare)
- Department of Cardiology, Karolinska Institutet and Karolinska University Hospital, C.L., L.M., Stockholm, Solna, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
-
visa färre...
-
(creator_code:org_t)
- NLM (Medline), 2021
- 2021
- Engelska.
-
Ingår i: Circulation. Cardiovascular Interventions. - : NLM (Medline). - 1941-7640 .- 1941-7632. ; 14:11, s. 1086-1093
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
https://gup.ub.gu.se...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: In patients with chronic coronary syndrome undergoing percutaneous coronary intervention, the optimal timing of P2Y12 inhibitors' administration is uncertain. We compared pretreatment versus treatment in the catheterization laboratory (In-Cathlab) in a real-world population.METHODS: In Swedish Coronary Angiography and Angioplasty Registry, all patients with chronic coronary syndrome undergoing coronary angiography and ad hoc percutaneous coronary intervention, between 2006 and 2017 were identified. Pretreatment was defined as P2Y12 inhibitor administration before coronary angiography, outside the catheterization laboratory. Outcomes were net adverse clinical events including death, myocardial infarction, stroke, or bleeding within 30 days of the index procedure and in-hospital bleeding.RESULTS: We included 26 814 patients, 8237 in the In-Cathlab, and 18 577 in the pretreatment group. In-Cathlab treatment compared with pretreatment was associated with lower risk for net adverse clinical event (4.2 versus 5.1%, adjusted hazard ratio 0.79 [0.63-0.99]), bleeding (2.3 versus 2.6%, adjusted hazard ratio, 0.76 [0.57-1.01]). and in-hospital bleeding (1.9 versus 2.1%, adjusted odds ratio, 0.70 [0.51-0.96]). The risk for death, myocardial infarction, or stroke did not significantly differ between the groups. Among the In-Cathlab treated patients, 41% received ticagrelor or prasugrel and 59% clopidogrel. Treatment with ticagrelor or prasugrel was associated with higher risk for net adverse clinical events (5.4% versus 3.4%, adjusted hazard ratio, 1.66 [1.12-2.48]), bleeding (3.4 versus 1.6%, adjusted hazard ratio, 2.14 [1.34-3.42]), and in-hospital bleeding (2.9 versus 1.2%, adjusted odds ratio, 2.24 [1.29-3.90]) but similar risk for death, myocardial infarction, or stroke, compared with clopidogrel.CONCLUSIONS: In patients with chronic coronary syndrome undergoing coronary angiography and ad hoc percutaneous coronary intervention, pretreatment with P2Y12 inhibitors, before arrival to the catheterization laboratory, was not associated with improved clinical outcomes but was associated with increased risk for bleeding. Our data support clopidogrel administration in the catheterization laboratory as the standard of care. Graphic Abstract: A graphic abstract is available for this article.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- angioplasty
- clopidogrel
- odds ratio
- percutaneous coronary intervention
- ticagrelor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jurga, Juliane
-
Szummer, Karolin ...
-
Lewinter, Christ ...
-
Mellbin, Linda
-
Götberg, Matthia ...
-
Zwackman, Sammy
-
visa fler...
-
Nilsson, Johan
-
Völz, Sebastian, ...
-
Erlinge, David
-
Persson, Jonas
-
Omerovic, Elmir, ...
-
Jernberg, Tomas
-
Venetsanos, Dimi ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Circulation. Car ...
- Av lärosätet
-
Umeå universitet
-
Karolinska Institutet
-
Linköpings universitet
-
Göteborgs universitet