Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes

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Fältnamn	Indikatorer	Metadata
000		03186naa a2200349 4500
001		oai:DiVA.org:umu-192956
003		SwePub
008		220307s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1929562 URI
024	7	a https://doi.org/10.1155/2022/54039952 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Zhang, Ainiu School of Medicine, Southeast University, Nanjing, China4 aut
245	1 0	a Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes
264	1	b Hindawi Publishing Corporation,c 2022
338		a electronic2 rdacarrier
520		a Corneal injury is a commonly encountered clinical problem which led to vision loss and impairment that affects millions of people worldwide. Currently, the available treatment in clinical practice is corneal transplantation, which is limited by the accessibility of donors. Corneal tissue engineering appears to be a promising alternative for corneal repair. However, current experimental strategies of corneal tissue engineering are insufficient due to inadequate differentiation of stem cell into keratocytes and thus cannot be applied in clinical practice. In this review, we aim to clarify the role and effectiveness of both biochemical factors, physical regulation, and the combination of both to induce stem cells to differentiate into keratocytes. We will also propose novel perspectives of differentiation strategy that may help to improve the efficiency of corneal tissue engineering.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oftalmologi0 (SwePub)302172 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Ophthalmology0 (SwePub)302172 hsv//eng
700	1	a Zhang, Weiu School of Medicine, Southeast University, Nanjing, China; Jiangsu Key Laboratory for Biomaterials and Devices Southeast University, Nanjing, China; China Orthopedic Regenerative Medicine Group, China4 aut
700	1	a Backman, Ludvig J.u Umeå universitet,Anatomi,Avdelningen för fysioterapi4 aut0 (Swepub:umu)lugban04
700	1	a Chen, Jialinu School of Medicine, Southeast University, Nanjing, China; Jiangsu Key Laboratory for Biomaterials and Devices Southeast University, Nanjing, China; China Orthopedic Regenerative Medicine Group, China4 aut
710	2	a School of Medicine, Southeast University, Nanjing, Chinab School of Medicine, Southeast University, Nanjing, China; Jiangsu Key Laboratory for Biomaterials and Devices Southeast University, Nanjing, China; China Orthopedic Regenerative Medicine Group, China4 org
773	0	t Stem Cells Internationald : Hindawi Publishing Corporationg 2022q 2022x 1687-9678x 1687-966X
856	4	u https://doi.org/10.1155/2022/5403995y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1642596/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://downloads.hindawi.com/journals/sci/2022/5403995.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-192956
856	4 8	u https://doi.org/10.1155/2022/5403995

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Av författaren/redakt...: Zhang, Aini; Zhang, Wei; Backman, Ludvig ...; Chen, Jialin

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Oftalmologi

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Av lärosätet: Umeå universitet

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