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Sökning: onr:"swepub:oai:DiVA.org:umu-193408" > Human antibody reco...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007011naa a2200637 4500
001oai:DiVA.org:umu-193408
003SwePub
008220331s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1934082 URI
0247 a https://doi.org/10.1126/scitranslmed.abl53992 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mittler, Evau Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut
2451 0a Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses
264 1b American Association for the Advancement of Science,c 2022
338 a print2 rdacarrier
520 a The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus (ANDV) and Sin Nombre virus, cause a distinct zoonotic disease, hantavirus cardiopulmonary syndrome (HCPS). Although these infections are severe and have substantial case fatality rates, no FDA-approved hantavirus countermeasures are available. Recent work suggests that monoclonal antibodies may have therapeutic utility. We describe here the isolation of human neutralizing antibodies (nAbs) against tetrameric Gn/Gc glycoprotein spikes from PUUV-experienced donors. We define a dominant class of nAbs recognizing the "capping loop" of Gn that masks the hydrophobic fusion loops in Gc. A subset of nAbs in this class, including ADI-42898, bound Gn/Gc complexes but not Gn alone, strongly suggesting that they recognize a quaternary epitope encompassing both Gn and Gc. ADI-42898 blocked the cell entry of seven HCPS- and HFRS-associated hantaviruses, and single doses of this nAb could protect Syrian hamsters and bank voles challenged with the highly virulent HCPS-causing ANDV and HFRS-causing PUUV, respectively. ADI-42898 is a promising candidate for clinical development as a countermeasure for both HCPS and HFRS, and its mode of Gn/Gc recognition informs the development of broadly protective hantavirus vaccines.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Wec, Anna Z.u Adimab, LLC, United States4 aut
7001 a Tynell, Janneu Umeå universitet,Institutionen för klinisk mikrobiologi,Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland4 aut0 (Swepub:umu)jaty0002
7001 a Guardado-Calvo, Pablou Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France4 aut
7001 a Wigren, Juliau Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)juwi0002
7001 a Polanco, Laura C.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut
7001 a O'Brien, Cecilia M.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States; The Geneva Foundation, Tacoma, WA 98402, USA4 aut
7001 a Slough, Megan M.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut
7001 a Abelson, Dafna M.u Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA4 aut
7001 a Serris, Alexandrau Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France4 aut
7001 a Sakharkar, Mrunalu Adimab, LLC, United States4 aut
7001 a Pehau-Arnaudet, Gerardu Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France4 aut
7001 a Bakken, Russell R.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States4 aut
7001 a Geoghegan, James C.u Adimab, LLC, United States4 aut
7001 a Jangra, Rohit K.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut
7001 a Keller, Markusu Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany4 aut
7001 a Zeitlin, Larryu Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA4 aut
7001 a Vapalahti, Olliu Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland; Veterinary Biosciences, Veterinary Faculty, University of Helsinki, Helsinki, Finland4 aut
7001 a Ulrich, Rainer G.u Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany; Deutsches Zentrum für Infektionsforschung, Partner site Hamburg-Lübeck- Borstel-Riems, Greifswald-Insel Riems, Germany4 aut
7001 a Bornholdt, Zachary A.u Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA4 aut
7001 a Ahlm, Clas,d 1956-u Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)clah0001
7001 a Rey, Felix A.u Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France4 aut
7001 a Dye, John M.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States4 aut
7001 a Bradfute, Steven B.u Center for Global Health, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, United States4 aut
7001 a Strandin, Tomasu Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland4 aut
7001 a Herbert, Andrew S.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States; The Geneva Foundation, Tacoma, WA 98402, USA4 aut
7001 a Forsell, Mattias N. E.u Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)mafo0173
7001 a Walker, Laura M.u Adimab, LLC, United States4 aut
7001 a Chandran, Kartiku Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut
7102 a Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USAb Adimab, LLC, United States4 org
7730 t Science Translational Medicined : American Association for the Advancement of Scienceg 14:636q 14:636x 1946-6234x 1946-6242
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193408
8564 8u https://doi.org/10.1126/scitranslmed.abl5399

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