Sökning: onr:"swepub:oai:DiVA.org:umu-193408" > Human antibody reco...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07011naa a2200637 4500 | |
001 | oai:DiVA.org:umu-193408 | |
003 | SwePub | |
008 | 220331s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1934082 URI |
024 | 7 | a https://doi.org/10.1126/scitranslmed.abl53992 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mittler, Evau Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut |
245 | 1 0 | a Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses |
264 | 1 | b American Association for the Advancement of Science,c 2022 |
338 | a print2 rdacarrier | |
520 | a The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus (ANDV) and Sin Nombre virus, cause a distinct zoonotic disease, hantavirus cardiopulmonary syndrome (HCPS). Although these infections are severe and have substantial case fatality rates, no FDA-approved hantavirus countermeasures are available. Recent work suggests that monoclonal antibodies may have therapeutic utility. We describe here the isolation of human neutralizing antibodies (nAbs) against tetrameric Gn/Gc glycoprotein spikes from PUUV-experienced donors. We define a dominant class of nAbs recognizing the "capping loop" of Gn that masks the hydrophobic fusion loops in Gc. A subset of nAbs in this class, including ADI-42898, bound Gn/Gc complexes but not Gn alone, strongly suggesting that they recognize a quaternary epitope encompassing both Gn and Gc. ADI-42898 blocked the cell entry of seven HCPS- and HFRS-associated hantaviruses, and single doses of this nAb could protect Syrian hamsters and bank voles challenged with the highly virulent HCPS-causing ANDV and HFRS-causing PUUV, respectively. ADI-42898 is a promising candidate for clinical development as a countermeasure for both HCPS and HFRS, and its mode of Gn/Gc recognition informs the development of broadly protective hantavirus vaccines. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
700 | 1 | a Wec, Anna Z.u Adimab, LLC, United States4 aut |
700 | 1 | a Tynell, Janneu Umeå universitet,Institutionen för klinisk mikrobiologi,Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland4 aut0 (Swepub:umu)jaty0002 |
700 | 1 | a Guardado-Calvo, Pablou Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France4 aut |
700 | 1 | a Wigren, Juliau Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)juwi0002 |
700 | 1 | a Polanco, Laura C.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut |
700 | 1 | a O'Brien, Cecilia M.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States; The Geneva Foundation, Tacoma, WA 98402, USA4 aut |
700 | 1 | a Slough, Megan M.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut |
700 | 1 | a Abelson, Dafna M.u Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA4 aut |
700 | 1 | a Serris, Alexandrau Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France4 aut |
700 | 1 | a Sakharkar, Mrunalu Adimab, LLC, United States4 aut |
700 | 1 | a Pehau-Arnaudet, Gerardu Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France4 aut |
700 | 1 | a Bakken, Russell R.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States4 aut |
700 | 1 | a Geoghegan, James C.u Adimab, LLC, United States4 aut |
700 | 1 | a Jangra, Rohit K.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut |
700 | 1 | a Keller, Markusu Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany4 aut |
700 | 1 | a Zeitlin, Larryu Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA4 aut |
700 | 1 | a Vapalahti, Olliu Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland; Veterinary Biosciences, Veterinary Faculty, University of Helsinki, Helsinki, Finland4 aut |
700 | 1 | a Ulrich, Rainer G.u Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany; Deutsches Zentrum für Infektionsforschung, Partner site Hamburg-Lübeck- Borstel-Riems, Greifswald-Insel Riems, Germany4 aut |
700 | 1 | a Bornholdt, Zachary A.u Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA4 aut |
700 | 1 | a Ahlm, Clas,d 1956-u Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)clah0001 |
700 | 1 | a Rey, Felix A.u Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France4 aut |
700 | 1 | a Dye, John M.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States4 aut |
700 | 1 | a Bradfute, Steven B.u Center for Global Health, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, United States4 aut |
700 | 1 | a Strandin, Tomasu Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland4 aut |
700 | 1 | a Herbert, Andrew S.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, United States; The Geneva Foundation, Tacoma, WA 98402, USA4 aut |
700 | 1 | a Forsell, Mattias N. E.u Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)mafo0173 |
700 | 1 | a Walker, Laura M.u Adimab, LLC, United States4 aut |
700 | 1 | a Chandran, Kartiku Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA4 aut |
710 | 2 | a Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USAb Adimab, LLC, United States4 org |
773 | 0 | t Science Translational Medicined : American Association for the Advancement of Scienceg 14:636q 14:636x 1946-6234x 1946-6242 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193408 |
856 | 4 8 | u https://doi.org/10.1126/scitranslmed.abl5399 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.