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Sökning: onr:"swepub:oai:DiVA.org:umu-198517" > Deep Brain Stimulat...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006444naa a2200493 4500
001oai:DiVA.org:umu-198517
003SwePub
008220808s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1985172 URI
0247 a https://doi.org/10.1002/mdc3.135102 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cappon, Davideu Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom; Hinda and Arthur Marcus Institute for Aging Research, Hebrew Senior Life, MA, Boston, United States; Deanna and Sidney Wolk Center for Memory Health, Hebrew Senior Life, MA, Boston, United States; Department of Neurology, Harvard Medical School, MA, Boston, United States4 aut
2451 0a Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson's Disease Dementia :b A 36 Months Follow Up Study
264 c 2022-07-27
264 1b John Wiley & Sons,c 2022
338 a electronic2 rdacarrier
520 a Background: Degeneration of the nucleus basalis of Meynert (NBM) and cortical cholinergic dysfunction are hallmarks of Parkinson's disease dementia (PDD). There is no effective therapy for PDD. Deep brain stimulation of the NBM (NBM-DBS) has been trialed as a potential treatment.Objective: Our primary aim was to evaluate the sustained tolerability of NBM-DBS in PDD, and its impact on global cognition, behavioral symptoms, quality of life and caregiver burden and distress. Second, we aimed to determine whether baseline measures of arousal, alertness, and attention were predictive of the three year response to NBM-DBS in PDD patients.Methods: Five of the six PDD patients who completed the baseline assessment participated in a 3 year follow up assessment. We assessed the participants after three years of NBM-DBS on the Mini Mental State Examination, Dementia Rating Scale-2, Blessed Dementia Rating Scale, Neuropsychiatric Inventory, and the SF36.Results: The five patients showed varying trajectories of cognitive decline, with two showing a slower progression over the three-year follow-up period. A slower progression of decline on global cognition was associated with higher baseline accuracy on the Posner covert orienting of attention test, and less daytime sleepiness.Conclusions: Whether slower progression of cognitive decline in two patients was in any way related to individual variability in responsiveness to NBM-DBS requires confirmation in a larger series including an unoperated PDD control group. Higher accuracy in covertly orienting attention and better sleep quality at baseline were associated with better cognitive outcomes at 36 months assessment. These results require validation in future studies with larger samples.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a cholinergic networks
653 a deep brain stimulation
653 a dementia
653 a nucleus basalis of Meynert
653 a Parkinson's disease dementia
653 a Neurology
653 a neurologi
7001 a Gratwicke, Jamesu Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Zrinzo, Ludvicu Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Akram, Harithu Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Hyam, Jonathanu Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Hariz, Marwanu Umeå universitet,Neurovetenskaper,Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut0 (Swepub:umu)hama0032
7001 a Limousin, Patriciau Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Foltynie, Thomasu Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Jahanshahi, Marjanu Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7102 a Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom; Hinda and Arthur Marcus Institute for Aging Research, Hebrew Senior Life, MA, Boston, United States; Deanna and Sidney Wolk Center for Memory Health, Hebrew Senior Life, MA, Boston, United States; Department of Neurology, Harvard Medical School, MA, Boston, United Statesb Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom4 org
7730 t Movement Disorders Clinical Practiced : John Wiley & Sonsg 9:6, s. 765-774q 9:6<765-774x 2330-1619
8564 u https://doi.org/10.1002/mdc3.13510y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1686136/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198517
8564 8u https://doi.org/10.1002/mdc3.13510

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