Sökning: onr:"swepub:oai:DiVA.org:umu-211153" > Structural and mech...
Fältnamn | Indikatorer | Metadata |
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000 | 06753naa a2200673 4500 | |
001 | oai:DiVA.org:umu-211153 | |
003 | SwePub | |
008 | 230703s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2111532 URI |
024 | 7 | a https://doi.org/10.1126/scitranslmed.adg18552 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mittler, Evau Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut |
245 | 1 0 | a Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody |
264 | 1 | b American Association for the Advancement of Science (AAAS),c 2023 |
338 | a print2 rdacarrier | |
520 | a Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (nAb) from a Puumala virus-experienced human donor. Here, we report its structure bound to its target, the Gn/Gc glycoprotein heterodimer comprising the viral fusion complex. The structure explains the broad activity of the nAb: It recognizes conserved Gc fusion loop sequences and the main chain of variable Gn sequences, thereby straddling the Gn/Gc heterodimer and locking it in its prefusion conformation. We show that the nAb's accelerated dissociation from the divergent Andes virus Gn/Gc at endosomal acidic pH limits its potency against this highly lethal virus and correct this liability by engineering an optimized variant that sets a benchmark as a candidate pan-hantavirus therapeutic. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
700 | 1 | a Serris, Alexandrau CNRS UMR3569, Structural Virology Unit, Institut Pasteur, Paris, France4 aut |
700 | 1 | a Esterman, Emma S.u Adimab LLC, Lebanon, NH,USA4 aut |
700 | 1 | a Florez, Catalinau U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States; The Geneva Foundation, Tacoma, WA, USA4 aut |
700 | 1 | a Polanco, Laura C.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut |
700 | 1 | a O'Brien, Cecilia M.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States; The Geneva Foundation, Tacoma, WA, USA4 aut |
700 | 1 | a Slough, Megan M.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut |
700 | 1 | a Tynell, Janneu Umeå universitet,Institutionen för klinisk mikrobiologi,Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland4 aut0 (Swepub:umu)jaty0002 |
700 | 1 | a Gröning, Remigiusu Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)regr0024 |
700 | 1 | a Sun, Yanu Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA4 aut |
700 | 1 | a Abelson, Dafna M.u Mapp Biopharmaceutical Inc., San Diego, CA, USA4 aut |
700 | 1 | a Wec, Anna Z.u Adimab LLC, Lebanon, NH, USA4 aut |
700 | 1 | a Haslwanter, Deniseu Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut |
700 | 1 | a Keller, Markusu Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany4 aut |
700 | 1 | a Ye, Chunyanu Center for Global Health, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, United States4 aut |
700 | 1 | a Bakken, Russel R.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States4 aut |
700 | 1 | a Jangra, Rohit K.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut |
700 | 1 | a Dye, John M.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States4 aut |
700 | 1 | a Ahlm, Clas,d 1956-u Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)clah0001 |
700 | 1 | a Rappazzo, C. Garrettu Adimab LLC, Lebanon, NH, USA4 aut |
700 | 1 | a Ulrich, Rainer G.u Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; Partner site: Hamburg-Lübeck-Borstel-Riems, German Centre for Infection Research (DZIF), Greifswald-Insel Riems, Germany4 aut |
700 | 1 | a Zeitlin, Larryu Mapp Biopharmaceutical Inc., San Diego, CA, USA4 aut |
700 | 1 | a Geoghegan, James C.u Adimab LLC, Lebanon, NH, USA4 aut |
700 | 1 | a Bradfute, Steven B.u Center for Global Health, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, United States4 aut |
700 | 1 | a Sidoli, Simoneu Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA4 aut |
700 | 1 | a Forsell, Mattias N. E.u Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)mafo0173 |
700 | 1 | a Strandin, Tomasu Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland4 aut |
700 | 1 | a Rey, Felix A.u CNRS UMR3569, Structural Virology Unit, Institut Pasteur, Paris, France4 aut |
700 | 1 | a Herbert, Andrew S.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States4 aut |
700 | 1 | a Walker, Laura M.u Adimab LLC, Lebanon, NH, USA4 aut |
700 | 1 | a Chandran, Kartiku Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut |
700 | 1 | a Guardado-Calvo, Pablou CNRS UMR3569, Structural Virology Unit, Institut Pasteur, Paris, France4 aut |
710 | 2 | a Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USAb CNRS UMR3569, Structural Virology Unit, Institut Pasteur, Paris, France4 org |
773 | 0 | t Science Translational Medicined : American Association for the Advancement of Science (AAAS)g 15:700q 15:700x 1946-6234x 1946-6242 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-211153 |
856 | 4 8 | u https://doi.org/10.1126/scitranslmed.adg1855 |
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