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Sökning: onr:"swepub:oai:DiVA.org:umu-212005" > Anti-neutrophil cyt...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006233naa a2200709 4500
001oai:DiVA.org:umu-212005
003SwePub
008230712s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-430235
009oai:lup.lub.lu.se:b960c680-b45f-4e39-8da1-19692bc3297d
009oai:DiVA.org:liu-174141
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2120052 URI
0247 a https://doi.org/10.1016/j.jaut.2020.1025792 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4302352 URI
0247 a https://lup.lub.lu.se/record/b960c680-b45f-4e39-8da1-19692bc3297d2 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1741412 URI
040 a (SwePub)umud (SwePub)uud (SwePub)lud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Berglin, Ewa,c MD, PhD,d 1955-u Umeå University,Umeå universitet,Reumatologi,Umea Univ, Sweden4 aut0 (Swepub:umu)evbe0009
2451 0a Anti-neutrophil cytoplasmic antibodies predate symptom onset of ANCA-associated vasculitis :b a case-control study
264 1b Elsevier,c 2021
338 a electronic2 rdacarrier
500 a Funding Agencies|Vasculitis foundation USA; Swedish Research CouncilSwedish Research CouncilEuropean Commission [K2013-52X-20307-07-3, 2018-02551]; King Gustaf Vs 80-Year Fund; Swedish Rheumatism Association; Umea University
520 a Objectives: Anti-neutrophil cytoplasmic autoantibodies [ANCA) are important for diagnosis of ANCA-associated vasculitides (AAV). The timing of antibody development is not well established. To investigate the development of proteinase 3 (PR3)- and myeloperoxidase (MPO)-ANCA, blood samples collected before onset of symptoms of AAV were analysed.Methods: To identify AAV patients with blood samples predating symptoms, the National Patient Register and Cause of Death register were scrutinized for ICD codes for AAV and linked to the registers of five biobanks. Diagnoses of AAV and time point for symptom onset were confirmed by reviewing 504 case-record. Eighty-five AAV cases (34 males, 51 females) with samples >1 month < 10 years from AAV symptom onset and two controls matched for sex, age, and sampling time for each case were included. Samples were screened using ELISAs for ANCA and further analysed for PR3-or MPO- specificities.Results: In ANCA-screen 35.7% of the pre-symptomatic cases and 3.5% of controls tested positive (p < 0.01). 26.2% of the cases were PR3-ANCA+ and 10.7% MPO-ANCA+. Median (Q1-Q3) predating time for PR3-ANCA+ was 2.7 (0.3–7.7) years and MPO-ANCA+ 2.0 (0.9–3.5) years. PR3-ANCA was demonstrated in samples up to nine years before symptom onset. At symptom onset predating PR3-ANCA+ cases were younger than PR3-ANCA- (P < 0.01), and MPO-ANCA+ were older than MPO-ANCA- (p < 0.05). Predating MPO-ANCA+ cases vs. MPO-ANCA- and vs. PR3-ANCA+ cases had more often at symptoms onset manifestations from lungs, kidneys or peripheral nervous system (p < 0.01 and p < 0.05, respectively).Conclusion: The PR3-and MPO-ANCAs are present years before AAV symptom onset and represent distinct diseases.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a AAV
653 a GPA
653 a MPA
653 a MPO-ANCA
653 a PR3-ANCA
653 a Predate symptom onset
653 a AAV
653 a GPA
653 a MPA
653 a MPO-ANCA
653 a PR3-ANCA
653 a Predate symptom onset
7001 a Mohammad, Aladdin J.u Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Cambridge,Lund Univ, Sweden; Univ Cambridge, England4 aut0 (Swepub:lu)reum-amo
7001 a Dahlqvist, Johanna,d 1979-u Uppsala University,Uppsala universitet,Reumatologi,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Sweden4 aut0 (Swepub:uu)johda205
7001 a Johansson, Lindau Umeå University,Umeå universitet,Reumatologi,Umea Univ, Sweden4 aut0 (Swepub:umu)lijo0115
7001 a Eriksson, Catharina,d 1955-u Umeå University,Umeå universitet,Klinisk immunologi,Umea Univ, Sweden4 aut0 (Swepub:umu)caaern74
7001 a Sjöwall, Johannau Linköpings universitet,Linköping University,Linköping University Hospital,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland4 aut0 (Swepub:liu)johfo45
7001 a Rantapää-Dahlqvist, Solbrittu Umeå University,Umeå universitet,Reumatologi,Umea Univ, Sweden4 aut0 (Swepub:umu)sora0001
7102 a Umeå universitetb Reumatologi4 org
7730 t Journal of Autoimmunityd : Elsevierg 117q 117x 0896-8411x 1095-9157
8564 u https://doi.org/10.1016/j.jaut.2020.102579y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1782052/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.jaut.2020.102579
8564 u https://uu.diva-portal.org/smash/get/diva2:1515192/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1016/j.jaut.2020.102579x freey FULLTEXT
8564 u https://liu.diva-portal.org/smash/get/diva2:1537230/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212005
8564 8u https://doi.org/10.1016/j.jaut.2020.102579
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430235
8564 8u https://lup.lub.lu.se/record/b960c680-b45f-4e39-8da1-19692bc3297d
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174141

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