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A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Aglago, Elom K. (författare)
Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
Kim, Andre (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Evangelou, Marina (författare)
Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
Ren, Yu (författare)
Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
Morrison, John (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, Liberia
Arndt, Volker (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Barry, Elizabeth L. (författare)
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
Baurley, James W. (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, Liberia
Bien, Stephanie A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Bishop, D Timothy (författare)
Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Bouras, Emmanouil (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Buchanan, Daniel D. (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia
Budiarto, Arif (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia
Carreras-Torres, Robert (författare)
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spain
Casey, Graham (författare)
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
Cenggoro, Tjeng Wawan (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Chan, Andrew T. (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
Chen, Xuechen (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany
Conti, David V. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Devall, Matthew (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Diez-Obrero, Virginia (författare)
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Dimou, Niki (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Drew, David (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Figueiredo, Jane C. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Gallinger, Steven (författare)
Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
Giles, Graham G. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
Gruber, Stephen B. (författare)
Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center
Gsur, Andrea (författare)
Center for Cancer Research, Medical University of Vienna, Vienna, Austria
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Hampel, Heather (författare)
Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi
Hidaka, Akihisa (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Huyghe, Jeroen R. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Jenkins, Mark A. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia
Jordahl, Kristina (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Joshi, Amit D. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Kawaguchi, Eric S. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Keku, Temitope O. (författare)
Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States
Kundaje, Anshul (författare)
Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
Larsson, Susanna C. (författare)
Karolinska Institutet
Marchand, Loic Le (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
Lewinger, Juan Pablo (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Li, Li (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Lynch, Brigid M. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia
Mahesworo, Bharuno (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Mandic, Marko (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany
Obón-Santacana, Mireia (författare)
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Moreno, Victor (författare)
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Nan, Hongmei (författare)
Department of Epidemiology, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States; IU Melvin and Bren Simon Cancer Center, Indiana University, IN, Indianapolis, United States
Nassir, Rami (författare)
Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Ogino, Shuji (författare)
Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States
Ose, Jennifer (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Pai, Rish K. (författare)
Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
Palmer, Julie R. (författare)
Department of Medicine, Boston University School of Medicine, Slone Epidemiology Center, Boston University, MA, Boston, United States
Papadimitriou, Nikos (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Pardamean, Bens (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Peoples, Anita R. (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Platz, Elizabeth A. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
Potter, John D. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
Prentice, Ross L. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
Ruiz-Narvaez, Edward (författare)
Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States
Sakoda, Lori C. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Scacheri, Peter C. (författare)
Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States
Schmit, Stephanie L. (författare)
Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States
Schoen, Robert E. (författare)
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
Shcherbina, Anna (författare)
Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
Slattery, Martha L. (författare)
Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
Stern, Mariana C. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Su, Yu-Ru (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Tangen, Catherine M. (författare)
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Thibodeau, Stephen N. (författare)
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
Thomas, Duncan C. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Tian, Yu (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China
Ulrich, Cornelia M. (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
van Duijnhoven, Franzel Jb (författare)
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
Vodicka, Pavel (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
Wang, Jun (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
White, Emily (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Wolk, Alicja (författare)
Karolinska Institutet
Woods, Michael O. (författare)
Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada
Wu, Anna H. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Zemlianskaia, Natalia (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
Gauderman, W James (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Tsilidis, Konstantinos K. (författare)
Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Campbell, Peter T. (författare)
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
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 (creator_code:org_t)
American Association For Cancer Research (AACR), 2023
2023
Engelska.
Ingår i: Cancer Research. - : American Association For Cancer Research (AACR). - 0008-5472 .- 1538-7445. ; 83:15, s. 2572-2583
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment interactions (G × E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G × E interactions between body mass index (BMI) and common SNPs for colorectal cancer risk using data from 36,415 colorectal cancer cases and 48,451 controls from three international colorectal cancer consortia (CCFR, CORECT, and GECCO). The G × E tests included the conventional logistic regression using multiplicative terms (one degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G × E interactions under specific conditions. BMI was associated with higher colorectal cancer risk. The two-step approach revealed a statistically significant G×BMI interaction located within the Formin 1/Gremlin 1 (FMN1/GREM1) gene region (rs58349661). This SNP was also identified by the 3DF test, with a suggestive statistical significance in the 1DF test. Among participants with the CC genotype of rs58349661, overweight and obesity categories were associated with higher colorectal cancer risk, whereas null associations were observed across BMI categories in those with the TT genotype. Using data from three large international consortia, this study discovered a locus in the FMN1/GREM1 gene region that interacts with BMI on the association with colorectal cancer risk. Further studies should examine the potential mechanisms through which this locus modifies the etiologic link between obesity and colorectal cancer.SIGNIFICANCE: This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies.

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MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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Aglago, Elom K.
Kim, Andre
Lin, Yi
Qu, Conghui
Evangelou, Marin ...
Ren, Yu
visa fler...
Morrison, John
Albanes, Demetri ...
Arndt, Volker
Barry, Elizabeth ...
Baurley, James W ...
Berndt, Sonja I.
Bien, Stephanie ...
Bishop, D Timoth ...
Bouras, Emmanoui ...
Brenner, Hermann
Buchanan, Daniel ...
Budiarto, Arif
Carreras-Torres, ...
Casey, Graham
Cenggoro, Tjeng ...
Chan, Andrew T.
Chang-Claude, Je ...
Chen, Xuechen
Conti, David V.
Devall, Matthew
Diez-Obrero, Vir ...
Dimou, Niki
Drew, David
Figueiredo, Jane ...
Gallinger, Steve ...
Giles, Graham G.
Gruber, Stephen ...
Gsur, Andrea
Gunter, Marc J.
Hampel, Heather
Harlid, Sophia, ...
Hidaka, Akihisa
Harrison, Tabith ...
Hoffmeister, Mic ...
Huyghe, Jeroen R ...
Jenkins, Mark A.
Jordahl, Kristin ...
Joshi, Amit D.
Kawaguchi, Eric ...
Keku, Temitope O ...
Kundaje, Anshul
Larsson, Susanna ...
Marchand, Loic L ...
Lewinger, Juan P ...
Li, Li
Lynch, Brigid M.
Mahesworo, Bharu ...
Mandic, Marko
Obón-Santacana, ...
Moreno, Victor
Murphy, Neil
Nan, Hongmei
Nassir, Rami
Newcomb, Polly A ...
Ogino, Shuji
Ose, Jennifer
Pai, Rish K.
Palmer, Julie R.
Papadimitriou, N ...
Pardamean, Bens
Peoples, Anita R ...
Platz, Elizabeth ...
Potter, John D.
Prentice, Ross L ...
Rennert, Gad
Ruiz-Narvaez, Ed ...
Sakoda, Lori C.
Scacheri, Peter ...
Schmit, Stephani ...
Schoen, Robert E ...
Shcherbina, Anna
Slattery, Martha ...
Stern, Mariana C ...
Su, Yu-Ru
Tangen, Catherin ...
Thibodeau, Steph ...
Thomas, Duncan C ...
Tian, Yu
Ulrich, Cornelia ...
van Duijnhoven, ...
van Guelpen, Bet ...
Visvanathan, Kal ...
Vodicka, Pavel
Wang, Jun
White, Emily
Wolk, Alicja
Woods, Michael O ...
Wu, Anna H.
Zemlianskaia, Na ...
Hsu, Li
Gauderman, W Jam ...
Peters, Ulrike
Tsilidis, Konsta ...
Campbell, Peter ...
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