Cryo-XPS for surface characterization of nanomedicines

Cant, David J. H. (författare): National Physical Laboratory, Teddington, UK

Marques, Sara S. (författare): Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal

Segundo, Marcela A. (författare): Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal

Parot, Jeremie (författare): Department of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway

Molska, Alicja (författare): Department of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway

Borgos, Sven E. (författare): Department of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway

Shard, Alexander G. (författare): National Physical Laboratory, Teddington, UK

Minelli, Caterina (författare): National Physical Laboratory, Teddington, UK

(creator_code:org_t)

American Chemical Society (ACS), 2023
2023
Engelska.
Ingår i: Journal of Physical Chemistry A. - : American Chemical Society (ACS). - 1089-5639 .- 1520-5215. ; 127:39, s. 8220-8227

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

Nanoparticles used for medical applications commonly possess coatings or surface functionalities intended to provide specific behavior in vivo, for example, the use of PEG to provide stealth properties. Direct, quantitative measurement of the surface chemistry and composition of such systems in a hydrated environment has thus far not been demonstrated, yet such measurements are of great importance for the development of nanomedicine systems. Here we demonstrate the first use of cryo-XPS for the measurement of two PEG-functionalized nanomedicines: a polymeric drug delivery system and a lipid nanoparticle mRNA carrier. The observed differences between cryo-XPS and standard XPS measurements indicate the potential of cryo-XPS for providing quantitative measurements of such nanoparticle systems in hydrated conditions.

Av författaren/redakt...: Cant, David J. H ...; Pei, Yiwen; Shchukarev, Andr ...; Ramstedt, Madele ...; Marques, Sara S.; Segundo, Marcela ...; visa fler...; Parot, Jeremie; Molska, Alicja; Borgos, Sven E.; Shard, Alexander ...; Minelli, Caterin ...; visa färre...

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