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  • Wirth, ThomasDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom; Neurology Department, Strasbourg University Hospital, Strasbourg, France; Institute of Genetics and Cellular and Molecular Biology, INSERM-U964, CNRS-UMR7104, University of Strasbourg, Strasbourg, France; Strasbourg Translational Medicine Federation, University of Strasbourg, Strasbourg, France (author)

Parkinson's disease tremor differentially responds to levodopa and subthalamic stimulation

  • Article/chapterEnglish2023

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  • John Wiley & Sons,2023
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-215391
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215391URI
  • https://doi.org/10.1002/mdc3.13876DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Background: Tremor in Parkinson's disease (PD) has an inconsistent response to levodopa and subthalamic deep brain stimulation (STN-DBS).Objectives: To identify predictive factors of PD tremor responsiveness to levodopa and STN-DBS.Material and Methods: PD patients with upper limb tremor who underwent STN-DBS were included. The levodopa responsiveness of tremor (overall, postural, and rest sub-components), was assessed using the relevant Unified Parkinson's Disease Rating Scale-III items performed during the preoperative assessment. Post-surgical outcomes were similarly assessed ON and OFF stimulation. A score for the rest/postural tremor ratio was used to determine the influence of rest and postural tremor severity on STN-DBS outcome. Factors predictive of tremor responsiveness were determined using multiple linear regression modeling. Volume of tissue activated measurement coupled to voxel-based analysis was performed to identify anatomical clusters associated with motor symptoms improvement.Results: One hundred and sixty five patients were included in this study. Male gender was negatively correlated with tremor responsiveness to levodopa, whereas the ratio of rest/postural tremor was positively correlated with both levodopa responsiveness and STN-DBS tremor outcome. Clusters corresponding to improvement of tremor were in the subthalamic nucleus, the zona incerta and the thalamus, whereas clusters corresponding to improvement for akinesia and rigidity were located within the subthalamic nucleus.Conclusion: More severe postural tremor and less severe rest tremor were associated with both poorer levodopa and STN-DBS response. The different locations of clusters associated with best correction of tremor and other parkinsonian features suggest that STN-DBS effect on PD symptoms is underpinned by the modulation of different networks.

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  • Ferreira, FranciscaDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom; Wellcome Centre for Human Neuroimaging, London, United Kingdom (author)
  • Vijiaratnam, NirosenDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom (author)
  • Girges, ChristineDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom (author)
  • Pakzad, AshkanEPSRC Centre for Doctoral Training i4health, University College London, London, United Kingdom (author)
  • de Roquemaurel, AlexisDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom (author)
  • Sinani, OlgaDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom (author)
  • Hyam, JonathanDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom (author)
  • Hariz, MarwanUmeå universitet,Neurovetenskaper,Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom(Swepub:umu)hama0032 (author)
  • Zrinzo, LudvicDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom (author)
  • Akram, HarithDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom (author)
  • Limousin, PatriciaDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom (author)
  • Foltynie, ThomasDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom (author)
  • Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom; Neurology Department, Strasbourg University Hospital, Strasbourg, France; Institute of Genetics and Cellular and Molecular Biology, INSERM-U964, CNRS-UMR7104, University of Strasbourg, Strasbourg, France; Strasbourg Translational Medicine Federation, University of Strasbourg, Strasbourg, FranceDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom; Wellcome Centre for Human Neuroimaging, London, United Kingdom (creator_code:org_t)

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  • In:Movement Disorders Clinical Practice: John Wiley & Sons10:11, s. 1639-16492330-1619

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