Real-world treatment patterns and outcomes for patients with multiple myeloma in Denmark, Finland and Sweden: An analysis using linked Nordic registries

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Real-world treatment patterns and outcomes for patients with multiple myeloma in Denmark, Finland and Sweden : An analysis using linked Nordic registries

Abildgaard, Niels (author): Hematology Research Unit, Department of Hematology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark

Anttila, Pekka (author): Comprehensive Cancer Center, Department of Hematology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland

Waage, Anders (author): Department of Hematology, St Olav's University Hospital, Trondheim, Norway

Rubin, Katrine Hass (author): Research Unit OPEN, Department of Clinical Research, University of Southern Denmark, Odense, Denmark

Ørstavik, Sigurd (author): Takeda Pharmaceuticals International AG, Oslo, Norway

Bent-Ennakhil, Nawal (author): Takeda Pharmaceuticals International AG, Zurich, Switzerland

Gavini, François (author): Takeda Pharmaceuticals International AG, Zurich, Switzerland

Ma, Yuanjun (author): Parexel International, Stockholm, Sweden

Freilich, Jonatan (author): Umeå universitet,Dermatologi och venereologi,Parexel International, Stockholm, Sweden

Hansson, Markus (author): Sahlgrenska Academy and Sahlgrenska University Hospital, Göteborg, Sweden

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Elsevier, 2024
2024
English.
In: European Journal of Cancer. - : Elsevier. - 0959-8049 .- 1879-0852. ; 201

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Aim: The Health outcomes and Understanding of MyelomA multi-National Study (HUMANS) was a large-scale, retrospective study conducted across Denmark, Finland and Sweden using linked data from national registries. We describe the characteristics, treatment patterns and clinical outcomes for patients with newly diagnosed multiple myeloma (NDMM) over 2010–2018.Methods: Patients with NDMM who received MM-specific, first-line treatments, were categorised by treatment (autologous stem cell transplantation [ASCT] or a combination chemotherapy regimen based on bortezomib, lenalidomide or melphalan-prednisolone-thalidomide).Results: 11,023 patients received treatment over 2010–2018. Time between diagnosis and treatment was shortest in Denmark (0.9 months), then Sweden (2.9 months) and Finland (4.6 months). Around one third of patients underwent ASCT. Lenalidomide-based regimens were prescribed to 23–28% of patients in Denmark and Finland, versus 12% in Sweden. Patients receiving lenalidomide had the longest wait for treatment, from 3.2 months (Denmark) to 12.1 months (Sweden). Treatment persistence was highest among patients receiving melphalan-prednisolone-thalidomide (7–8 months) in Finland and Sweden and lowest among those receiving bortezomib (3.5 months) in Finland. Overall survival (OS) was longest among patients with ASCT (7–10 years). Among patients receiving chemotherapy, OS (from diagnosis/treatment initiation), varied between cohorts. In a sensitivity analysis excluding patients with smouldering MM, OS decreased for all; for patients receiving bortezomib or lenalidomide, OS from diagnosis was 40–49 and 27–54 months, respectively.Conclusions: This population-based study of patients with NDMM receiving first-line MM-specific treatment, provides real-world data on treatment patterns and outcomes to complement data from randomised clinical trials.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)

Keyword

Bortezomib
Lenalidomide
Melphalan
Multiple myeloma
Nordic registries
Outcomes
Real world
Survival
Treatment patterns

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By the author/editor: Abildgaard, Niel ...; Anttila, Pekka; Waage, Anders; Rubin, Katrine H ...; Ørstavik, Sigurd; Bent-Ennakhil, N ...; show more...; Gavini, François; Ma, Yuanjun; Freilich, Jonata ...; Hansson, Markus; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

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By the university: Umeå University

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