Search: onr:"swepub:oai:DiVA.org:umu-31988" >
Dopamine D(1) recep...
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Bäckman, LarsStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
Dopamine D(1) receptors and age differences in brain activation during working memory
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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Fayetteville, N.Y :Elsevier,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-31988
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31988URI
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https://doi.org/10.1016/j.neurobiolaging.2009.10.018DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123212753URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-94949URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [(11)C] SCH23390 to determine dopamine D(1) receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load>lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D(1) BP in caudate and DLPFC. Statistical control of caudate and DLPFC D(1) binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Karlsson, SariStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Fischer, HåkanStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Psykologiska institutionen(Swepub:su)hkfi4392
(author)
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Karlsson, PerKarolinska Institutet
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Brehmer, YvonneStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Rieckmann, AnnaStockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)(Swepub:umu)anri0051
(author)
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Macdonald, Stuart WSAging Research Center, Karolinska Institutet, Gävlegatan 16, SE-113 30 Stockholm, Sweden; Department of Psychology, University of Victoria, Canada
(author)
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Farde, LarsKarolinska Institutet
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Nyberg, LarsUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)lany0001
(author)
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Karolinska InstitutetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
Related titles
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In:Neurobiology of AgingFayetteville, N.Y : Elsevier32:10, s. 1849-18560197-45801558-1497
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