Search: onr:"swepub:oai:DiVA.org:umu-33075" >
AML and Ets protein...
AML and Ets proteins regulate the I alpha1 germ-line promoter.
-
- Xie, Xiao-Qi (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
- Pardali, Evangelia (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
- Holm, Magnus (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
show more...
-
- Sideras, Paschalis (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
- Grundström, Thomas (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
show less...
-
(creator_code:org_t)
- 1999
- 1999
- English.
-
In: European Journal of Immunology. - 0014-2980 .- 1521-4141. ; 29:2, s. 488-498
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The immunoglobulin heavy chain (IgH) class switch recombination of B lymphocytes preferentially targets unrearranged IgH genes that have already been rendered transcriptionally active. Transcription of the germ-line IgH genes is controlled by intervening (I) regions upstream of their switch regions. The I alpha1 promoter activates transcription of the human germ-line C alpha1 gene for IgA1 and mediates the transforming growth factor (TGF)-beta1 responsiveness of this locus. Here we show that the I alpha1 promoter contains several binding sites for the AML/PEBP2/CBF family of transcription factors and that AML and Ets proteins are major regulators of the basal and TGF-beta-inducible promoter activity. Our data constitute a starting point for studies to elucidate the molecular mechanism by which TGF-beta regulates IgA production.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database