onr:"swepub:oai:DiVA.org:umu-43346"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03356naa a2200433 4500 | |
| 001 | oai:DiVA.org:umu-43346 | |
| 003 | SwePub | |
| 008 | 110427s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-433462 URI |
| 024 | 7 | a https://doi.org/10.1093/ANATOX/35.4.2422 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kronstrand, Robertu National Board of Forensic Medicine4 aut |
| 245 | 1 0 | a Unintentional fatal intoxications with mitragynine and O-Desmethyltramadol from the herbal blend krypton |
| 264 | 1 | c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a The leaves of Kratom, a medicinal plant in Southeast Asia, have been used as an herbal drug for a long time. At least one of the alkaloids present in Kratom, mitraynine, is a mu-receptor agonist. Both Kratom and an additional preparation called Krypton are available via the internet. It seems to consist of powdered Kratom leaves with another mu-receptor agonist, O-desmethyltramadol added. O-desmethyltramadol is an acitve metabolite of tramadol, a commonly prescribed analgesic. We present nine cases of intoxication, occurring in a period of less than one year, where both mitragynine and O-desmethyltramadol were detected in the postmortem blood samples. neither tramadol nor N-desmethyltramadol was present in these samples, which implies that the ingested drug was O-desmethyltramadol. The blood concentrations of mitragynine, determined by ultra-performance liquid chromatography-tandem mass spectrometry, ranged from 0.02 to 0.18 μg/g, and O-desmethyltramadol concentrations, determined by gas chromatogtraphy with nitrogen-specific detection, ranged from 0.4 to 4.3 μg/g. We believe that the addition of the potent mu-receptor agonist O-desmethyltramadol to powdered leaves from Kratom contributed to the unintentional death of the nine cases presented and conclude that intake of Krypton is not as harmless as it often is described on internet websites. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Rättsmedicin0 (SwePub)305012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Forensic Science0 (SwePub)305012 hsv//eng |
| 653 | a Krypton | |
| 653 | a O-Desmethyltramadol | |
| 653 | a Toxicology | |
| 653 | a Toxikologi | |
| 653 | a Forensic medicine | |
| 653 | a Rättsmedicin | |
| 653 | a Forensic Medicine | |
| 653 | a rättsmedicin | |
| 700 | 1 | a Roman, Markusu National Board of Forensic Medicine4 aut |
| 700 | 1 | a Thelander, Gunillau National Board of Forensic Medicine4 aut |
| 700 | 1 | a Eriksson, Andersu Umeå universitet,Rättsmedicin4 aut0 (Swepub:umu)aner0001 |
| 710 | 2 | a National Board of Forensic Medicineb Rättsmedicin4 org |
| 773 | 0 | t Journal of Analytical Toxicologyg 35:4, s. 242-247q 35:4<242-247x 0146-4760x 1945-2403 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43346 |
| 856 | 4 8 | u https://doi.org/10.1093/ANATOX/35.4.242 |
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