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T Cells in Tumors a...
T Cells in Tumors and Blood Predict Outcome in Follicular Lymphoma Treated with Rituximab
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- Wahlin, Björn Engelbrekt (author)
- Karolinska Institutet
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- Sundström, Christer (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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Holte, Harald (author)
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- Hagberg, Hans (author)
- Uppsala universitet,Enheten för onkologi
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- Erlanson, Martin (author)
- Umeå universitet,Onkologi
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- Nilsson-Ehle, Herman, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Lindén, Ola (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Nordström, Marie (author)
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Ostenstad, Bjørn (author)
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Geisler, Christian H (author)
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Brown, Peter de Nully (author)
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Lehtinen, Tuula (author)
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Maisenhölder, Martin (author)
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Tierens, Anne M (author)
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- Sander, Birgitta (author)
- Karolinska Institutet
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- Christensson, Birger (author)
- Karolinska Institutet
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- Kimby, Eva (author)
- Karolinska Institutet
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(creator_code:org_t)
- American Association for Cancer Research, 2011
- 2011
- English.
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In: Clinical Cancer Research. - : American Association for Cancer Research. - 1078-0432 .- 1557-3265. ; 17:12, s. 4136-4144
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Abstract
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- PURPOSE: T cells influence outcome in follicular lymphoma, but their contributions seem to be modified by therapy. Their impact in patients receiving rituximab without chemotherapy is unknown. EXPERIMENTAL DESIGN: Using flow cytometry, we evaluated the T cells in tumors and/or blood in a total of 250 follicular lymphoma patients included in two Nordic Lymphoma Group randomized trials that compared single rituximab with IFN-α2a-rituximab combinations. RESULTS: In univariate analysis, higher levels of CD3(+), CD4(+), and CD8(+) T cells in both tumors and blood correlated with superior treatment responses, and in multivariate analysis, tumor-CD3(+) (P = 0.011) and blood-CD4(+) (P = 0.029) cells were independent. CD4(+) cells were favorable regardless of treatment arm, but CD8(+) cells were favorable only in patients treated with single rituximab, because IFN-α2a improved responses especially in patients with low CD8(+) cell levels. Higher levels of blood-CD3(+) (P = 0.003) and blood-CD4(+) (P = 0.046) cells predicted longer overall survival, and higher levels of blood-CD8(+) cells longer times to next treatment (P = 0.046). CONCLUSIONS: We conclude that therapeutic effects of rituximab are augmented by tumor-associated T cells for rapid responses and by systemic T cells for sustained responses. CD4(+) and CD8(+) cells are both favorable in patients treated with rituximab. IFN-α2a abrogates the negative impact of few CD8(+) cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Oncology
- Onkologi
- Oncology
- onkologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wahlin, Björn En ...
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Sundström, Chris ...
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Holte, Harald
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Hagberg, Hans
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Erlanson, Martin
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Nilsson-Ehle, He ...
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show more...
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Lindén, Ola
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Nordström, Marie
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Ostenstad, Bjørn
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Geisler, Christi ...
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Brown, Peter de ...
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Lehtinen, Tuula
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Maisenhölder, Ma ...
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Tierens, Anne M
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Sander, Birgitta
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Christensson, Bi ...
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Kimby, Eva
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Clinical Cancer ...
- By the university
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Umeå University
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Uppsala University
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Karolinska Institutet
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University of Gothenburg
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Lund University