onr:"swepub:oai:DiVA.org:umu-46252"
Sökning: onr:"swepub:oai:DiVA.org:umu-46252" > Computational analy...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02719naa a2200361 4500 | |
| 001 | oai:DiVA.org:umu-46252 | |
| 003 | SwePub | |
| 008 | 110829s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-462522 URI |
| 024 | 7 | a https://doi.org/10.1261/rna.10728082 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nissan, Tracyu University of Arizona, Tucson, Arizona, USA4 aut0 (Swepub:umu)trni0004 |
| 245 | 1 0 | a Computational analysis of miRNA-mediated repression of translation :b implications for models of translation initiation inhibition |
| 264 | c 2008-06-25 | |
| 264 | 1 | b Cold Spring Harbor Laboratory,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a The mechanism by which miRNAs inhibit translation has been under scrutiny both in vivo and in vitro. Divergent results have led to the suggestion that miRNAs repress translation by a variety of mechanisms including blocking the function of the cap in stimulating translation. However, these analyses largely only examine the final output of the multistep process of translation. This raises the possibility that when different steps in translation are rate limiting, miRNAs might show different effects on protein production. To examine this possibility, we modeled the process of translation initiation and examined how the effects of miRNAs under different conditions might be explained. Our results suggest that different effects of miRNAs on protein production in separate experiments could be due to differences in rate-limiting steps. This analysis does not rule out that miRNAs directly repress the function of the cap structure, but it demonstrates that the observations used to argue for this effect are open to alternative interpretations. Taking all the data together, our analysis is consistent with the model that miRNAs may primarily repress translation initiation at a late step. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 653 | a miRNA | |
| 653 | a modeling | |
| 653 | a repression | |
| 653 | a translation | |
| 700 | 1 | a Parker, Roy4 aut |
| 710 | 2 | a University of Arizona, Tucson, Arizona, USA4 org |
| 773 | 0 | t RNAd : Cold Spring Harbor Laboratoryg 14:8, s. 1480-1491q 14:8<1480-1491x 1355-8382x 1469-9001 |
| 856 | 4 | u http://rnajournal.cshlp.org/content/14/8/1480.full.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46252 |
| 856 | 4 8 | u https://doi.org/10.1261/rna.1072808 |
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