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Concentrations of I...
Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European prospective investigation into cancer and nutrition
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Rohrmann, Sabine (author)
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Linseisen, Jakob (author)
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Becker, Susen (author)
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Allen, Naomi (author)
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Schlehofer, Brigitte (author)
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Overvad, Kim (author)
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Olsen, Anja (author)
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Tjønneland, Anne (author)
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- Melin, Beatrice S (author)
- Umeå universitet,Onkologi
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Lund, Eiliv (author)
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Vineis, Paolo (author)
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Grioni, Sara (author)
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Tumino, Rosario (author)
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Palli, Domenico (author)
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Mattiello, Amalia (author)
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Bonet, Catalina (author)
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Chirlaque, Maria-Dolores (author)
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Sánchez, María-José (author)
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Rodríguez, Laudina (author)
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Dorronsoro, Miren (author)
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Ardanaz, Eva (author)
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Lagiou, Pagona (author)
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Trichopoulou, Antonia (author)
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Trichopoulos, Dimitrios (author)
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Dossus, Laure (author)
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Grote, Verena A (author)
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Boeing, Heiner (author)
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Aleksandrova, Krasimira (author)
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Bueno-de-Mesquita, H Bas (author)
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van Duijnhoven, Fränzel J B (author)
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Peeters, Petra H M (author)
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Khaw, Kay-Tee (author)
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Wareham, Nicholas J (author)
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Key, Timothy J (author)
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Rinaldi, Sabina (author)
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Romieux, Isabelle (author)
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Gallo, Valentina (author)
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Michaud, Dominique S (author)
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Riboli, Elio (author)
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Kaaks, Rudolf (author)
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 20:10, s. 2174-2182
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development. METHODS: We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. IGF-I and IGFBP-3 were measured by ELISAs.Conditional logistic regression was used to compute ORs and corresponding 95% CIs. RESULTS: The risk of low-grade gliomas was elevated with increased IGF-I (OR = 3.60, 95% CI: 1.11-11.7; top vs. bottom quartile) and decreased with elevated IGFBP-3 concentrations (OR = 0.28, 95% CI: 0.09-0.84) after mutual adjustment of these two factors; these results became nonsignificant after exclusion of the first year of follow-up. No association was observed for high-grade gliomas or meningiomas. Both high IGF-I and IGFBP-3 concentrations were associated with risk of acoustic neuromas (IGF-I: OR = 6.63, 95% CI: 2.27-19.4, top vs. bottom tertile; IGFBP-3: OR = 7.07, 95% CI: 2.32-21.6), even after excluding the first year of follow-up. CONCLUSION: High concentrations of IGF-I might be positively associated with risk of low-grade gliomas and acoustic neuromas, although we cannot exclude reverse causation, in particular for low-grade gliomas. Impact: Factors of the IGF axis might be involved in the etiology of some types of brain tumors. Cancer Epidemiol Biomarkers Prev; ©2011 AACR.
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- By the author/editor
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Rohrmann, Sabine
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Linseisen, Jakob
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Becker, Susen
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Allen, Naomi
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Schlehofer, Brig ...
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Overvad, Kim
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show more...
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Olsen, Anja
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Tjønneland, Anne
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Melin, Beatrice ...
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Lund, Eiliv
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Vineis, Paolo
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Grioni, Sara
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Tumino, Rosario
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Palli, Domenico
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Mattiello, Amali ...
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Bonet, Catalina
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Chirlaque, Maria ...
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Sánchez, María-J ...
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Rodríguez, Laudi ...
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Dorronsoro, Mire ...
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Ardanaz, Eva
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Lagiou, Pagona
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Dossus, Laure
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Grote, Verena A
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Boeing, Heiner
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Aleksandrova, Kr ...
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Bueno-de-Mesquit ...
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van Duijnhoven, ...
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Peeters, Petra H ...
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Key, Timothy J
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Rinaldi, Sabina
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Romieux, Isabell ...
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Gallo, Valentina
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Michaud, Dominiq ...
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Riboli, Elio
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Kaaks, Rudolf
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show less...
- Articles in the publication
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Cancer Epidemiol ...
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Umeå University