Lowering apolipoprotein CIII delays onset of type 1 diabetes

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Fältnamn	Indikatorer	Metadata
000		02613naa a2200397 4500
001		oai:DiVA.org:umu-57947
003		SwePub
008		120821s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:122831740
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-579472 URI
024	7	a https://doi.org/10.1073/pnas.10195531082 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1228317402 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Holmberg, Rebecka4 aut
245	1 0	a Lowering apolipoprotein CIII delays onset of type 1 diabetes
264		c 2011-06-13
264	1	b National Academy of Sciences,c 2011
338		a print2 rdacarrier
520		a Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that apoCIII was also increased in sera from prediabetic rats. This increase in apoCIII promoted β-cell death. The endogenous levels of apoCIII were reduced by treating prediabetic animals with an antisense against this apolipoprotein, resulting in a significantly delayed onset of diabetes. ApoCIII thus serves as a diabetogenic factor, and intervention with this apolipoprotein in the prediabetic state can arrest disease progression. These findings suggest apoCIII as a target for the treatment of type 1 diabetes.
700	1	a Refai, Essamu Karolinska Institutet4 aut
700	1	a Höög, Andersu Karolinska Institutet4 aut
700	1	a Crooke, Rosanne M4 aut
700	1	a Graham, Mark4 aut
700	1	a Olivecrona, Gunillau Umeå universitet,Fysiologisk kemi4 aut0 (Swepub:umu)guol0002
700	1	a Berggren, Per-Olofu Karolinska Institutet4 aut
700	1	a Juntti-Berggren, Lisau Karolinska Institutet4 aut
710	2	a Karolinska Institutetb Fysiologisk kemi4 org
773	0	t Proceedings of the National Academy of Sciences of the United States of Americad : National Academy of Sciencesg 108:26, s. 10685-10689q 108:26<10685-10689x 0027-8424x 1091-6490
856	4	u https://www.pnas.org/content/pnas/108/26/10685.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-57947
856	4 8	u https://doi.org/10.1073/pnas.1019553108
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:122831740

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Av författaren/redakt...: Holmberg, Rebeck ...; Refai, Essam; Höög, Anders; Crooke, Rosanne ...; Graham, Mark; Olivecrona, Guni ...; visa fler...; Berggren, Per-Ol ...; Juntti-Berggren, ...; visa färre...

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Av lärosätet: Umeå universitet; Karolinska Institutet

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