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Cultured granulosa ...
Cultured granulosa cells produce two plasminogen activators and an antiactivator, each regulated differently by gonadotropins.
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- Ny, Tor (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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Bjersing, L (author)
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Hsueh, A J (author)
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Loskutoff, D J (author)
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(creator_code:org_t)
- 1985
- 1985
- English.
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In: Endocrinology. - 0013-7227 .- 1945-7170. ; 116:4, s. 1666-8
- Related links:
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https://urn.kb.se/re...
Abstract
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- Although treatment of cultured granulosa cells with gonadotropins increases their fibrinolytic activity, the biochemical nature of this effect is unclear. We have used sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and fibrin autography techniques to characterize the fibrinolytic components secreted by granulosa cells. The fibrinolytic activity of these cells results from the production of both a tissue-type plasminogen activator (t-PA) and a urokinase-like activator (u-PA). The cells also produce an inhibitor of fibrinolysis (antiactivator). FSH and LH stimulate t-PA activity and suppress antiactivator activity, while u-PA activity is not affected by the gonadotropins. The differential regulation of these molecules by the gonadotropins may be essential for ovulation.
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- art (subject category)
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