Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies

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Hruby, Adela (author)

Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies

Article/chapterEnglish2013

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Elsevier BV,2013
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LIBRIS-ID:oai:DiVA.org:umu-67583
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-67583URI
https://doi.org/10.3945/jn.112.172049DOI
https://lup.lub.lu.se/record/3671535URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197380URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:126230314URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (In-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [beta = -0.009 mmol/L (95% CI: -0.013, -0.005), P< 0.0001] and insulin (-0.020 In-pmo/L (95% CI: -0.024, -0.017), P< 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P= 0.03) with glucose, and rs11558471 in SLC30A8and rs3740393 near CNNM2showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. J. Nutr. 143: 345-353, 2013.

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Ngwa, Julius S. (author)
Renström, FridaLund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-frm (author)
Wojczynski, Mary K. (author)
Ganna, AndreaKarolinska Institutet (author)
Hallmans, GöranUmeå universitet,Näringsforskning,Enheten för biobanksforskning(Swepub:umu)goha0001 (author)
Houston, Denise K. (author)
Franks, PaulUmeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin(Swepub:umu)pafr0003 (author)
Kanoni, Stavroula (author)
Lehtimaki, Terho (author)
Lemaitre, Rozenn N. (author)
Manichaikul, Ani (author)
North, Kari E. (author)
Ntalla, Ioanna (author)
Sonestedt, EmilyLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-eso (author)
Tanaka, Toshiko (author)
van Rooij, Frank J. A. (author)
Bandinelli, Stefania (author)
Djousse, Luc (author)
Grigoriou, Efi. (author)
Johansson, IngegerdUmeå universitet,Tandläkarutbildning(Swepub:umu)injo0003 (author)
Lohman, Kurt K. (author)
Pankow, James S. (author)
Raitakari, Olli T. (author)
Riserus, UlfUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (author)
Yannakoulia, Mary (author)
Zillikens, M. Carola (author)
Hassanali, Neelam (author)
Liu, Yongmei (author)
Mozaffarian, Dariush (author)
Papoutsakis, Constantina (author)
Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin(Swepub:uu)anncsyva (author)
Uitterlinden, Andre G. (author)
Viikari, Jorma (author)
Groves, Christopher J. (author)
Hofman, Albert (author)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
McCarthy, Mark I. (author)
Mikkila, Vera (author)
Mukamal, Kenneth (author)
Franco, Oscar H. (author)
Borecki, Ingrid B. (author)
Cupples, L. Adrienne (author)
Dedoussis, George V. (author)
Ferrucci, Luigi (author)
Hu, Frank B. (author)
Ingelsson, Erik (author)
Kahonen, Mika (author)
Kao, W. H. Linda (author)
Kritchevsky, Stephen B. (author)
Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (author)
Prokopenko, Inga (author)
Rotter, Jerome I. (author)
Siscovick, David S. (author)
Witteman, Jacqueline C. M. (author)
Franks, Paul W.Umeå universitet,Medicin(Swepub:umu)pafr0003 (author)
Meigs, James B. (author)
McKeown, Nicola M. (author)
Nettleton, Jennifer A. (author)
Umeå universitetMedicin (creator_code:org_t)

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In:Journal of Nutrition: Elsevier BV143:3, s. 345-3530022-31661541-6100

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By the author/editor: Hruby, Adela; Ngwa, Julius S.; Renström, Frida; Wojczynski, Mary ...; Ganna, Andrea; Hallmans, Göran; show more...; Houston, Denise ...; Franks, Paul; Kanoni, Stavroul ...; Lehtimaki, Terho; Lemaitre, Rozenn ...; Manichaikul, Ani; North, Kari E.; Ntalla, Ioanna; Sonestedt, Emily; Tanaka, Toshiko; van Rooij, Frank ...; Bandinelli, Stef ...; Djousse, Luc; Grigoriou, Efi.; Johansson, Ingeg ...; Lohman, Kurt K.; Pankow, James S.; Raitakari, Olli ...; Riserus, Ulf; Yannakoulia, Mar ...; Zillikens, M. Ca ...; Hassanali, Neela ...; Liu, Yongmei; Mozaffarian, Dar ...; Papoutsakis, Con ...; Syvänen, Ann-Chr ...; Uitterlinden, An ...; Viikari, Jorma; Groves, Christop ...; Hofman, Albert; Lind, Lars; McCarthy, Mark I ...; Mikkila, Vera; Mukamal, Kenneth; Franco, Oscar H.; Borecki, Ingrid ...; Cupples, L. Adri ...; Dedoussis, Georg ...; Ferrucci, Luigi; Hu, Frank B.; Ingelsson, Erik; Kahonen, Mika; Kao, W. H. Linda; Kritchevsky, Ste ...; Orho-Melander, M ...; Prokopenko, Inga; Rotter, Jerome I ...; Siscovick, David ...; Witteman, Jacque ...; Franks, Paul W.; Meigs, James B.; McKeown, Nicola ...; Nettleton, Jenni ...; show less...

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