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Sökning: onr:"swepub:oai:DiVA.org:umu-82666" > Expression profilin...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004105naa a2200493 4500
001oai:DiVA.org:umu-82666
003SwePub
008131106s2002 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-826662 URI
0247 a https://doi.org/10.1152/physiolgenomics.00115.20012 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fischer, M Dominiku University of Pennsylvania School of Medicine4 aut
2451 0a Expression profiling reveals metabolic and structural components of extraocular muscles
264 1b American Physiological Society,c 2002
338 a print2 rdacarrier
520 a The extraocular muscles (EOM) are anatomically and physiologically distinct from other skeletal muscles. EOM are preferentially affected in mitochondrial myopathies, but spared in Duchenne's muscular dystrophy. The anatomical and pathophysiological properties of EOM have been attributed to their unique molecular makeup: an allotype. We used expression profiling to define molecular features of the EOM allotype. We found 346 differentially expressed genes in rat EOM compared with tibialis anterior, based on a twofold difference cutoff. Genes required for efficient, fatigue-resistant, oxidative metabolism were increased in EOM, whereas genes for glycogen metabolism were decreased. EOM also showed increased expression of genes related to structural components of EOM such as vessels, nerves, mitochondria, and neuromuscular junctions. Additionally, genes related to specialized functional roles of EOM such as the embryonic and EOM-specific myosin heavy chains and genes for muscle growth, development, and/or regeneration were increased. The EOM expression profile was validated using biochemical, structural, and molecular methods. Characterization of the EOM expression profile begins to define gene transcription patterns associated with the unique anatomical, metabolic, and pathophysiological properties of EOM.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
653 a extraocular muscle
653 a allotype
653 a expression profile
653 a transcriptome
653 a energy metabolism
7001 a Gorospe, J Rafaelu George Washington University, Washington4 aut
7001 a Felder, Edwardu University of Pennsylvania School of Medicine, Philadelphia4 aut
7001 a Bogdanovich, Sashau University of Pennsylvania School of Medicine4 aut
7001 a Pedrosa-Domellöf, Fatimau Umeå universitet,Anatomi4 aut0 (Swepub:umu)fape0001
7001 a Ahima, Rexford Su University of Pennsylvania School of Medicine, Philadelphia4 aut
7001 a Rubinstein, Neal Au University of Pennsylvania School of Medicine, Philadelphia4 aut
7001 a Hoffman, Eric Pu George Washington University, Washington4 aut
7001 a Khurana, Tejvir Su University of Pennsylvania School of Medicine4 aut
7102 a University of Pennsylvania School of Medicineb George Washington University, Washington4 org
7730 t Physiological Genomicsd : American Physiological Societyg 9:2, s. 71-84q 9:2<71-84x 1094-8341x 1531-2267
8564 u http://physiolgenomics.physiology.org/content/9/2/71
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82666
8564 8u https://doi.org/10.1152/physiolgenomics.00115.2001

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