SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:umu-82687"
 

Search: onr:"swepub:oai:DiVA.org:umu-82687" > Localization of lam...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003902naa a2200529 4500
001oai:DiVA.org:umu-82687
003SwePub
008131106s2002 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1939117
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-826872 URI
0247 a https://doi.org/10.1177/0022155402050008132 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19391172 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Petäjäniemi, Noorau University of Helsinki4 aut
2451 0a Localization of laminin alpha4-chain in developing and adult human tissues
264 c 2016-06-26
264 1b SAGE Publications,c 2002
338 a print2 rdacarrier
520 a Recent studies suggest important functions for laminin-8 (Ln-8; alpha4beta1gamma1) in vascular and blood cell biology, but its distribution in human tissues has remained elusive. We have raised a monoclonal antibody (MAb) FC10, and by enzyme-linked immunoassay (EIA) and Western blotting techniques we show that it recognizes the human Ln alpha4-chain. Immunoreactivity for the Ln alpha4-chain was localized in tissues of mesodermal origin, such as basement membranes (BMs) of endothelia, adipocytes, and skeletal, smooth, and cardiac muscle cells. In addition, the Ln alpha4-chain was found in regions of some epithelial BMs, including epidermis, salivary glands, pancreas, esophageal and gastric glands, intestinal crypts, and some renal medullary tubules. Developmental differences in the distribution of Ln alpha4-chain were detected in skeletal muscle, walls of vessels, and intestinal crypts. Ln alpha4- and Ln alpha2-chains co-localized in BMs of fetal skeletal muscle cells and in some epithelial BMs, e.g., in gastric glands and acini of pancreas. Cultured human pulmonary artery endothelial (HPAE) cells produced Ln alpha4-chain as M(r) 180,000 and 200,000 doublet and rapidly deposited it to the growth substratum. In cell-free extracellular matrices of human kidney and lung, Ln alpha4-chain was found as M(r) 180,000 protein.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653 a basement membrane
653 a laminin-8
653 a alpha 4-chain
653 a monoclonal antibody
653 a endothelial cell
7001 a Korhonen, Mattiu Helsinki University Central Hospital4 aut
7001 a Kortesmaa, Jarkkou Karolinska Institute and BioStratum AB, Stockholm4 aut
7001 a Tryggvason, Karlu Karolinska Institutet4 aut
7001 a Sekiguchi, Kiyotoshiu Osaka University4 aut
7001 a Fujiwara, Hironobuu Osaka University4 aut
7001 a Sorokin, Lydiau IZKF Nachwuchsgruppe II, Nikolaus Fiebiger Center, Erlangen, Germany4 aut
7001 a Thornell, Lars-Ericu Umeå universitet,Anatomi4 aut0 (Swepub:umu)lath0002
7001 a Wondimu, Zenebechu Karolinska Institute4 aut
7001 a Assefa, Danielu Karolinska Institute4 aut
7001 a Patarroyo, Manuelu Karolinska Institutet4 aut
7001 a Virtanen, Ismou University of Helsinki4 aut
7102 a University of Helsinkib Helsinki University Central Hospital4 org
7730 t Journal of Histochemistry and Cytochemistryd : SAGE Publicationsg 50:8, s. 1113-1130q 50:8<1113-1130x 0022-1554x 1551-5044
8564 u https://journals.sagepub.com/doi/pdf/10.1177/002215540205000813
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82687
8564 8u https://doi.org/10.1177/002215540205000813
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1939117

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view