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  • Belz, Gabrielle TImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia (author)

The CD8alpha+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens.

  • Article/chapterEnglish2002

Publisher, publication year, extent ...

  • 2002-10-14
  • The Rockefeller University Press,2002
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-87524
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87524URI
  • https://doi.org/10.1084/jem.20020861DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We previously described a mechanism for the maintenance of peripheral self-tolerance. This involves the cross-presentation of tissue-associated antigens by a bone marrow-derived cell type that stimulates the proliferation and ultimate deletion of self-reactive CD8 T cells. This process has been referred to as cross-tolerance. Here, we characterize the elusive cell type responsible for inducing cross-tolerance as a CD8alpha(+) dendritic cell (DC). To achieve this aim, transgenic mice were generated expressing yellow fluorescent protein (YFP) linked to CTL epitopes for ovalbumin and glycoprotein B (gB) of herpes simplex virus under the rat insulin promoter (RIP). Although tracking of YFP was inconclusive, the use of a highly sensitive gB-specific hybridoma that produced beta-galactosidase on encounter with antigen, enabled detection of antigen presentation by cells isolated from the pancreatic lymph node. This showed that a CD11c(+)CD8alpha(+) cell was responsible for cross-tolerance, the same DC subset as previously implicated in cross-priming. These data indicate that CD8alpha(+) DCs play a critical role in both tolerance and immunity to cell-associated antigens, providing a potential mechanism by which cytotoxic T lymphocyte can be immunized to viral antigens while maintaining tolerance to self.

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  • Behrens, Georg M NImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia (author)
  • Smith, Chris MImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia (author)
  • Miller, Jacques F A PImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia (author)
  • Jones, ClaerwenDepartment of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia (author)
  • Lejon, Kristina,1967-Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA(Swepub:umu)krle0001 (author)
  • Fathman, C. GarrisonDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA (author)
  • Mueller, Scott NDepartment of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia (author)
  • Shortman, KenImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia (author)
  • Carbone, Francis RDepartment of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia (author)
  • Heath, William RImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia (author)
  • Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, AustraliaDepartment of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia (creator_code:org_t)

Related titles

  • In:Journal of Experimental Medicine: The Rockefeller University Press196:8, s. 1099-11040022-10071540-9538

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