Sökning: onr:"swepub:oai:DiVA.org:umu-97593" > Prolactin Determina...
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000 | 04963naa a2200781 4500 | |
001 | oai:DiVA.org:umu-97593 | |
003 | SwePub | |
008 | 141223s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:130135327 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-975932 URI |
024 | 7 | a https://doi.org/10.1158/1055-9965.EPI-14-06132 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1301353272 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tikk, Kaja4 aut |
245 | 1 0 | a Prolactin Determinants in Healthy Women :b A Large Cross-Sectional Study within the EPIC Cohort |
264 | 1 | c 2014 |
338 | a print2 rdacarrier | |
520 | a Background: Experimental and epidemiologic data suggest that higher circulating prolactin is associated with breast cancer risk; however, how various risk factors for breast cancer influence prolactin levels in healthy women is not clear. Methods: We analyzed cross-sectional associations between several suggested reproductive and lifestyle risk factors for breast cancer and circulating prolactin among pre- and postmenopausal women, taking into account the use of current postmenopausal hormone therapy, among 2,560 controls from a breast cancer nested case-control study within the EPIC cohort. Results: Adjusted geometric mean prolactin levels were significantly higher among premenopausal women, and among postmenopausal women using hormone therapy compared with nonusers (8.2, 7.0, and 6.3 ng/mL, respectively; P-cat = <0.0001). Furthermore, prolactin levels were significantly higher among users of combined estrogen-progestin hormone therapy compared with users of estrogen-alone hormone therapy (6.66 vs. 5.90 ng/mL; P-cat = 0.001). Prolactin levels were lower among parous women compared with nulliparous women (8.61 vs. 10.95 ng/mL; P-cat = 0.0002, premenopausal women); the magnitude of this difference depended on the number of full-term pregnancies (22.1% lower, >= 3 vs. 1 pregnancy, P-trend = 0.01). Results for parity were similar but lower in magnitude among postmenopausal women. Prolactin did not vary by other studied factors, with the exception of lower levels among postmenopausal smokers compared with never smokers. Conclusions: Our study shows that current hormone therapy use, especially the use of combined hormone therapy, is associated with higher circulating prolactin levels in postmenopausal women, and confirms prior findings of lower circulating prolactin in parous women. Impact: Our study extends the knowledge linking various breast cancer risk factors with circulating prolactin. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Sookthai, Disorn4 aut |
700 | 1 | a Johnson, Theron4 aut |
700 | 1 | a Dossus, Laure4 aut |
700 | 1 | a Clavel-Chapelon, Francoise4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Olsen, Anja4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Baglietto, Laura4 aut |
700 | 1 | a Rinaldi, Sabina4 aut |
700 | 1 | a Romieu, Isabelle4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Masala, Giovanna4 aut |
700 | 1 | a Agnoli, Claudia4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Sacerdote, Carlotta4 aut |
700 | 1 | a Mattiello, Amalia4 aut |
700 | 1 | a Buckland, Genevieve4 aut |
700 | 1 | a Sanchez, Soledad4 aut |
700 | 1 | a Molina-Montes, Esther4 aut |
700 | 1 | a Amiano, Pilar4 aut |
700 | 1 | a Huerta Castano, Jose Maria4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Bueno-de-Mesquita, H. Bas4 aut |
700 | 1 | a Monninkhof, Evelyn M.4 aut |
700 | 1 | a Onland-Moret, N. Charlotte4 aut |
700 | 1 | a Idahl, Annikau Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)anid0002 |
700 | 1 | a Lundin, Evau Umeå universitet,Patologi4 aut0 (Swepub:umu)evlu0001 |
700 | 1 | a Weider-pass, Elisabete4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Waaseth, Marit4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Key, Timothy J.4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Gunter, Marc J.4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
710 | 2 | a Umeå universitetb Obstetrik och gynekologi4 org |
773 | 0 | t Cancer Epidemiology, Biomarkers and Preventiong 23:11, s. 2532-2542q 23:11<2532-2542x 1055-9965x 1538-7755 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97593 |
856 | 4 8 | u https://doi.org/10.1158/1055-9965.EPI-14-0613 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130135327 |
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