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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003449naa a2200397 4500
001oai:DiVA.org:uu-105402
003SwePub
008090603s2008 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1054022 URI
0247 a https://doi.org/10.1186/bcr18632 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Eerola, Hannaleena4 aut
2451 0a Basal cytokeratins in breast tumours among BRCA1, BRCA2 and mutation-negative breast cancer families
264 c 2008-02-14
264 1b Springer Science and Business Media LLC,c 2008
338 a print2 rdacarrier
520 a INTRODUCTION: Finding new immunohistochemical markers that are specific to hereditary breast cancer could help us to select candidates for BRCA1/BRCA2 mutation testing and to understand the biological pathways of tumour development. METHODS: Using breast cancer tumour microarrays, immunohistochemical expression of cytokeratin (CK)-5/6, CK-14 and CK-17 was evaluated in breast tumours from BRCA1 families (n = 46), BRCA2 families (n = 40), non-BRCA1/BRCA2 families (n = 358) and familial breast cancer patients with one first-degree relative affected by breast or ovarian cancer (n = 270), as well as from patients with sporadic breast cancer (n = 364). Staining for CK-5/6, CK-14 and CK-17 was compared between these groups and correlated with other clinical and histological factors. RESULTS: CK-5/6, CK-14 and CK-17 were detected mostly among oestrogen receptor (ER)-negative, progesterone receptor (PR)-negative and high-grade tumours. We found the highest percentages of samples positive for these CKs among ER-negative/HER2-negative tumours. In univariate analysis, CK-14 was significantly associated with tumours from BRCA1 (39%; P < 0.0005), BRCA2 (27%; P = 0.011), and non-BRCA1/BRCA2 (21%; P < 0.005) families, as compared with sporadic tumours (10%). However, in multivariate analysis, CKs were not found to be independently associated with BRCA1 or BRCA2 mutation status, and the most effective predictors of BRCA1 mutations were age at onset, HER2 status, and either ER or PR status. CONCLUSION: Although our study confirms that basal CKs can help to identify BRCA1 mutation carriers, this effect was weaker than previously suggested and CKs did not independently predict BRCA1 mutation either from sporadic or familial breast cancer cases. The most effective, independent predictors of BRCA1 mutations were age at onset, HER2 status, and either ER or PR status, as compared with sporadic or non-BRCA1/BRCA2 cancers.
653 a MEDICINE
653 a MEDICIN
7001 a Heinonen, Mira4 aut
7001 a Heikkilä, Päivi4 aut
7001 a Kilpivaara, Outi4 aut
7001 a Tamminen, Anitta4 aut
7001 a Aittomäki, Kristiina4 aut
7001 a Blomqvist, Carlu Uppsala universitet,Enheten för onkologi4 aut
7001 a Ristimäki, Ari4 aut
7001 a Nevanlinna, Heli4 aut
7102 a Uppsala universitetb Enheten för onkologi4 org
7730 t Breast cancer research : BCRd : Springer Science and Business Media LLCg 10:1, s. R17-q 10:1<R17-x 1465-542X
8564 u https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/bcr1863
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105402
8564 8u https://doi.org/10.1186/bcr1863

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