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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004670naa a2200493 4500
001oai:DiVA.org:uu-113864
003SwePub
008100204s2009 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-25328
009oai:prod.swepub.kib.ki.se:119162773
009oai:DiVA.org:liu-19896
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1138642 URI
0247 a https://doi.org/10.1258/jms.2009.0081032 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-253282 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1191627732 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198962 URI
040 a (SwePub)uud (SwePub)umud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Holmberg, Larsu Uppsala universitet,Endokrinkirurgi,Kings College London4 aut0 (Swepub:uu)lahol021
2451 0a Differences in endpoints between the Swedish W-E (two county) trial of mammographic screening and the Swedish overview :b methodological consequences
264 c 2009-06-29
264 1b SAGE Publications,c 2009
338 a print2 rdacarrier
520 a OBJECTIVES: To characterize and quantify the differences in the number of cases and breast cancer deaths in the Swedish W-E Trial compared with the Swedish Overview Committee (OVC) summaries and to study methodological issues related to trials in secondary prevention. SETTING: The study population of the W-E Trial of mammography screening was included in the first (W and E county) and the second (E-county) OVC summary of all Swedish randomized mammography screening trials. The OVC and the W-E Trial used different criteria for case definition and causes of death determination. METHOD: A Review Committee compared the original data files from W and E county and the first and second OVC. The reason for a discrepancy was determined individually for all non-concordant cases or breast cancer deaths. RESULTS: Of the 2615 cases included by the W-E Trial or the OVC, there were 478 (18%) disagreements. Of the disagreements 82% were due to inclusion/exclusion criteria, and 18% to disagreement with respect to cause of death or vital status at ascertainment. For E-County, the OVC inclusion rules and register based determination of cause of death (second OVC) rather than individual case review (W-E Trial and 1st OVC) resulted in a reduction of the estimate of the effect of screening, but for W-County the difference between the original trial and the OVC was modest. CONCLUSIONS: The conclusion that invitation to mammography screening reduces breast cancer mortality remains robust. Disagreements were mainly due to study design issues, while disagreements about cause of death were a minority. When secondary research does not adhere to the protocols of the primary research projects, the consequences of such design differences should be investigated and reported. Register linkage of trials can add follow-up information. The precision of trials with modest size is enhanced by individual monitoring of case status and outcome status such as determination of cause of death.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a MEDICINE
653 a MEDICIN
7001 a Duffy, S. W.u Wolfson Institute for Preventative Medicine4 aut
7001 a Yen, A. M.u Wolfson Institute for Preventative Medicine4 aut
7001 a Tabár, L.u Uppsala University4 aut
7001 a Vitak, B.u Östergötlands Läns Landsting,Linköpings universitet,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping4 aut
7001 a Nyström, Lennarthu Umeå universitet,Epidemiologi och folkhälsovetenskap,Umea University4 aut0 (Swepub:umu)leny0002
7001 a Frisell, J.u Karolinska Institutet,Karolinska Institute4 aut
7102 a Uppsala universitetb Endokrinkirurgi4 org
7730 t Journal of Medical Screeningd : SAGE Publicationsg 16:2, s. 73-80q 16:2<73-80x 0969-1413x 1475-5793
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113864
8564 8u https://doi.org/10.1258/jms.2009.008103
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25328
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:119162773
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19896

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