onr:"swepub:oai:DiVA.org:uu-127514"
Sökning: onr:"swepub:oai:DiVA.org:uu-127514" > Antiviral treatment...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02922naa a2200421 4500 | |
| 001 | oai:DiVA.org:uu-127514 | |
| 003 | SwePub | |
| 008 | 100713s2009 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:119396952 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1275142 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1348-0421.2009.00160.x2 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1193969522 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Holmberg, Rebecka4 aut |
| 245 | 1 0 | a Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats |
| 264 | 1 | b Wiley,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a The effects of LV in two different species, CD-1 mice, without a genetic disposition for diabetes, and BB rats prone to T1D were examined. Male CD-1 mice that had been exposed to LV in utero developed a type 2-like diabetes with increased blood glucose, insulin levels and epididymal fat at the age of 10-15 weeks. Combination therapy including LV-antiserum and an antiviral drug, Pleconaril, significantly reduced the levels of blood glucose and insulin and the amount of abdominal fat. In BB rats, LV has been found in both prediabetic- and diabetic diabetes-prone rats, as well as in diabetes-resistant rats. To evaluate whether the presence of LV has any influence on the onset of T1D, prediabetic BB rats were treated with an antiserum against LV or a combination of the antiviral drugs Pleconaril and Ribavirin. In the group treated with antiviral drugs, the onset was significantly delayed. These results indicate that the presence of LV can be involved in the pathogenesis of diabetes in these animal models. | |
| 653 | a antibody treatment | |
| 653 | a antiviral therapy | |
| 653 | a viral infection | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Klitz, William4 aut |
| 700 | 1 | a Blixt, Martinu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)mabli254 |
| 700 | 1 | a Berggren, Per-Olofu Karolinska Institutet4 aut |
| 700 | 1 | a Juntti-Berggren, Lisau Karolinska Institutet4 aut |
| 700 | 1 | a Niklasson, Bou Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)boani125 |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinsk cellbiologi4 org |
| 773 | 0 | t Microbiology and immunologyd : Wileyg 53:10, s. 567-572q 53:10<567-572x 0385-5600x 1348-0421 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1348-0421.2009.00160.x |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-127514 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1348-0421.2009.00160.x |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:119396952 |
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