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Sökning: onr:"swepub:oai:DiVA.org:uu-138210" > The receptor locus ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003486naa a2200445 4500
001oai:DiVA.org:uu-138210
003SwePub
008101216s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1382102 URI
0247 a https://doi.org/10.1007/s00335-010-9305-32 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rampoldi, Antonio4 aut
2451 0a The receptor locus for Escherichia coli F4ab/F4ac in the pig maps distal to the MUC4-LMLN region
264 c 2010-12-07
264 1b Springer Science and Business Media LLC,c 2011
338 a print2 rdacarrier
520 a Enterotoxigenic Escherichia coli (ETEC) with fimbriae of the F4 family are one of the major causes of diarrhea and death among neonatal and young piglets. Bacteria use the F4 fimbriae to adhere to specific receptors expressed on the surface of the enterocytes. F4 fimbriae exist in three different antigenic variants, F4ab, F4ac, and F4ad, of which F4ac is the most common. Resistance to ETEC F4ab/F4ac adhesion in pigs has been shown to be inherited as an autosomal recessive trait. In previous studies the ETEC F4ab/F4ac receptor locus (F4bcR) was mapped to the q41 region on pig chromosome 13. A polymorphism within an intron of the mucin 4 (MUC4) gene, which is one of the possible candidate genes located in this region, was shown earlier to cosegregate with the F4bcR alleles. Recently, we discovered a Large White boar from a Swiss experimental herd with a recombination between F4bcR and MUC4. A three-generation pedigree including 45 offspring was generated with the aim to use this recombination event to refine the localization of the F4bcR locus. All pigs were phenotyped using the microscopic adhesion test and genotyped for a total of 59 markers. The recombination event was mapped to a 220-kb region between a newly detected SNP in the leishmanolysin-like gene (LMLN g.15920) and SNP ALGA0072075. In this study the six SNPs ALGA0072075, ALGA0106330, MUC13-226, MUC13-813, DIA0000584, and MARC0006918 were in complete linkage disequilibrium with F4bcR. Based on this finding and earlier investigations, we suggest that the locus for F4bcR is located between the LMLN locus and microsatellite S0283.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a Biology
653 a Biologi
7001 a Jacobsen, Mette J.4 aut
7001 a Bertschinger, Hans U.4 aut
7001 a Joller, David4 aut
7001 a Bürgi, Esther4 aut
7001 a Vögeli, Peter4 aut
7001 a Andersson, Leifu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)leand227
7001 a Archibald, Alan L.4 aut
7001 a Fredholm, Merete4 aut
7001 a Jørgensen, Claus B.4 aut
7001 a Neuenschwander, Stefan4 aut
7102 a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org
7730 t Mammalian Genomed : Springer Science and Business Media LLCg 22:1-2, s. 122-129q 22:1-2<122-129x 0938-8990x 1432-1777
8564 u https://www.research-collection.ethz.ch/bitstream/20.500.11850/26882/2/335_2010_Article_9305.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-138210
8564 8u https://doi.org/10.1007/s00335-010-9305-3

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