onr:"swepub:oai:DiVA.org:uu-172019"
Sökning: onr:"swepub:oai:DiVA.org:uu-172019" > Somatic mutations i...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02332naa a2200397 4500 | |
| 001 | oai:DiVA.org:uu-172019 | |
| 003 | SwePub | |
| 008 | 120401s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1720192 URI |
| 024 | 7 | a https://doi.org/10.1002/gcc.219352 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jiao, Xiangu Uppsala universitet,Genomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)xiaji705 |
| 245 | 1 0 | a Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers |
| 264 | c 2012-02-03 | |
| 264 | 1 | b Wiley,c 2012 |
| 338 | a print2 rdacarrier | |
| 520 | a Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved. | |
| 700 | 1 | a Wood, Laura D.4 aut |
| 700 | 1 | a Lindman, Monicau Uppsala universitet,Genomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)monli420 |
| 700 | 1 | a Jones, Sian4 aut |
| 700 | 1 | a Buckhaults, Phillip4 aut |
| 700 | 1 | a Polyak, Kornelia4 aut |
| 700 | 1 | a Sukumar, Saraswati4 aut |
| 700 | 1 | a Carter, Hannah4 aut |
| 700 | 1 | a Kim, Dewey4 aut |
| 700 | 1 | a Karchin, Rachel4 aut |
| 700 | 1 | a Sjöblom, Tobiasu Uppsala universitet,Genomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)tobisjob |
| 710 | 2 | a Uppsala universitetb Genomik4 org |
| 773 | 0 | t Genes, Chromosomes and Cancerd : Wileyg 51:5, s. 480-489q 51:5<480-489x 1045-2257x 1098-2264 |
| 856 | 4 | u https://europepmc.org/articles/pmc3302210?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172019 |
| 856 | 4 8 | u https://doi.org/10.1002/gcc.21935 |
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