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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002687naa a2200385 4500
001oai:DiVA.org:uu-17231
003SwePub
008080618s2007 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172312 URI
024a https://doi.org/10.1016/S0079-6123(06)62010-42 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
100a Sharma, Hari Shankeru Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care4 aut0 (Swepub:uu)hssharma
2451 0a Methods to produce hyperthermia-induced brain dysfunction
264 1c 2007
338 a print2 rdacarrier
520 a The recent increase in the frequency and intensity of killer heat waves across the globe has aroused worldwide medical attention to exploring therapeutic strategies to attenuate heat-related morbidity and/or mortality. Death due to heat-related illnesses often exceeds >50% of heat victims. Those who survive are crippled with lifetime disabilities and exhibit profound cognitive, sensory, and motor dysfunction akin to premature neurodegeneration. Although more than 50% of the world populations are exposed to summer heat waves; our understanding of detailed underlying mechanisms and the suitable therapeutic strategies have still not been worked out. One of the basic reasons behind this is the lack of a reliable experimental model to simulate clinical hyperthermia. This chapter describes a suitable animal model to induce hyperthermia in rats (or mice) comparable to the clinical situation. The model appears to be useful for studying the effects of heat-related illnesses on changes in various organs and systems, including the central nervous system (CNS). Since hyperthermia is often associated with profound brain dysfunction, additional methods to examine some crucial parameters of brain injury, e.g., blood-brain barrier (BBB) breakdown and brain edema formation, are also described.
653 a hyperthermia
653 a brain dysfunction
653 a cell injury
653 a blood-brain barrier
653 a brain edema
653 a rectal temperature
653 a anesthetics
653 a heat stress
653 a heat stroke
653 a MEDICINE
653 a MEDICIN
710a Uppsala universitetb Institutionen för kirurgiska vetenskaper4 org
773t Progress in Brain Researchg 162, s. 173-199q 162<173-199x 0079-6123x 1875-7855
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-17231
8564 8u https://doi.org/10.1016/S0079-6123(06)62010-4

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