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MYC+ diffuse large ...
MYC+ diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation
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Cuccuini, Wendy (författare)
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Briere, Josette (författare)
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Mounier, Nicolas (författare)
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Voelker, Hans-Ullrich (författare)
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Rosenwald, Andreas (författare)
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- Sundström, Christer (författare)
- Uppsala universitet,Molekylär och morfologisk patologi
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Cogliatti, Sergio (författare)
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Hirchaud, Edouard (författare)
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Ysebaert, Loic (författare)
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Bron, Dominique (författare)
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Soulier, Jean (författare)
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Gaulard, Philippe (författare)
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Houlgatte, Remi (författare)
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Gisselbrecht, Christian (författare)
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Thieblemont, Catherine (författare)
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(creator_code:org_t)
- American Society of Hematology, 2012
- 2012
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 119:20, s. 4619-4624
- Relaterad länk:
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https://ashpublicati...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Approximately 5-10% of diffuse large B-cell lymphomas (DLBCL) harbor a 8q24/MYC rearrangement (MYC+). We determined the prognostic significance of MYC rearrangement in patients with relapsed/refractory DLBCL prospectively treated by R-ICE or R-DHAP followed by highdose therapy and autologous stem cell transplantation. Twenty-eight (17%) of the 161 patients analyzed presented a MYC+ rearrangement, targeted as either simple hit (25%) or complex hits (n = 75%) including MYC/BCL2, MYC/BCL6, and MYC/BCL2/BCL6. Results were statistically highly concordant in matched primary and relapsed biopsies (n = 45). Compared to the MYC+ DLBCL patients, the MYC+ DLBCL patients presented with a more elevated lactico-deshydrogenase level (P = .0006) and a more advanced age adjusted international prognostic index (P = .0039). The 4-year PFS and OS were significantly lower in the MYC+ DLBCL patients than those in the MYC- DLBCL patients, with rates of 18% vs 42% (P = .0322), and of 29% vs 62% (P = .0113), respectively. Type of treatment, R-DHAP or R-ICE, had no impact on survivals, with 4-year PFS rates of 17% vs 19% and 4-year OS rates of 26% vs 31%. In conclusion, MYC rearrangement is an early event in DLBCL. MYC+ DLBCL patients have a significant inferior prognosis than MYC- DLBCL patients. Their outcome was not influenced by the proposed salvage therapy.
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Blood
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Cuccuini, Wendy
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Briere, Josette
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Mounier, Nicolas
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Voelker, Hans-Ul ...
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Rosenwald, Andre ...
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Sundström, Chris ...
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visa fler...
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Cogliatti, Sergi ...
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Hirchaud, Edouar ...
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Ysebaert, Loic
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Bron, Dominique
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Soulier, Jean
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Gaulard, Philipp ...
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Houlgatte, Remi
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Gisselbrecht, Ch ...
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Thieblemont, Cat ...
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visa färre...
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Uppsala universitet