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Plasma alkylresorci...
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Magnusdottir, O. K.
(author)
Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity : a randomized study
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-02-19
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Springer Science and Business Media LLC,2014
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-224340
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224340URI
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https://doi.org/10.1038/ejcn.2014.12DOI
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https://res.slu.se/id/publ/66813URI
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https://lup.lub.lu.se/record/4334477URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128602410URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND/OBJECTIVES: Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS). SUBJECTS/METHODS: Participants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND + control) regression analyses at 18/24 weeks. RESULTS: ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks. CONCLUSIONS: The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS.
Subject headings and genre
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Landberg, RikardSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science,Karolinska Institute(Swepub:slu)51036
(author)
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Gunnarsdottir, I.
(author)
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Cloetens, LLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)tbio-lce
(author)
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Akesson, BLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Skåne University Hospital(Swepub:lu)kc-bak
(author)
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Landin-Olsson, MonaLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-mla
(author)
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Rosqvist, FredrikUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)frero353
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Iggman, DavidUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)davig338
(author)
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Schwab, U.
(author)
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Herzig, K-H
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Savolainen, M. J.
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Brader, L.
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Hermansen, K.
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Kolehmainen, M.
(author)
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Poutanen, K.
(author)
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Uusitupa, MattiUppsala universitet,Klinisk nutrition och metabolism
(author)
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Thorsdottir, I.
(author)
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Risérus, UlfUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser
(author)
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Sveriges lantbruksuniversitetInstitutionen för livsmedelsvetenskap
(creator_code:org_t)
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Sveriges lantbruksuniversitet
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In:European Journal of Clinical Nutrition: Springer Science and Business Media LLC68:4, s. 453-4580954-30071476-5640
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Magnusdottir, O. ...
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Landberg, Rikard
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Gunnarsdottir, I ...
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Cloetens, L
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Akesson, B
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Landin-Olsson, M ...
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Rosqvist, Fredri ...
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Iggman, David
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Schwab, U.
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Herzig, K-H
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Savolainen, M. J ...
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Brader, L.
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Hermansen, K.
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Kolehmainen, M.
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Poutanen, K.
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Uusitupa, Matti
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Thorsdottir, I.
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Risérus, Ulf
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- MEDICAL AND HEALTH SCIENCES
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Uppsala University
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Swedish University of Agricultural Sciences
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Lund University
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Karolinska Institutet