Search: onr:"swepub:oai:DiVA.org:uu-238747" > New functions and s...
Fältnamn | Indikatorer | Metadata |
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000 | 03511naa a2200673 4500 | |
001 | oai:DiVA.org:uu-238747 | |
003 | SwePub | |
008 | 141216s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2387472 URI |
024 | 7 | a https://doi.org/10.1111/nyas.125802 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Liebscher, Ines4 aut |
245 | 1 0 | a New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors |
264 | c 2014-11-25 | |
264 | 1 | b Wiley,c 2014 |
338 | a print2 rdacarrier | |
520 | a The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGPCRs but one (GPR123) contain a GPCR autoproteolysis-inducing (GAIN) domain that mediates autoproteolytic cleavage at the GPCR autoproteolysis site motif to generate N- and a C-terminal fragments (NTF and CTF, respectively) during protein maturation. Subsequently, the NTF and CTF are associated noncovalently as a heterodimer at the plasma membrane. While the biological function of the GAIN domain-mediated autocleavage is not fully understood, mounting evidence suggests that the NTF and CTF possess distinct biological activities in addition to their function as a receptor unit. We discuss recent advances in understanding the biological functions, signaling mechanisms, and disease associations of the aGPCRs. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Ackley, Brian4 aut |
700 | 1 | a Araç, Demet4 aut |
700 | 1 | a Ariestanti, Donna M4 aut |
700 | 1 | a Aust, Gabriela4 aut |
700 | 1 | a Bae, Byoung-Il4 aut |
700 | 1 | a Bista, Bigyan R4 aut |
700 | 1 | a Bridges, James P4 aut |
700 | 1 | a Duman, Joseph G4 aut |
700 | 1 | a Engel, Felix B4 aut |
700 | 1 | a Giera, Stefanie4 aut |
700 | 1 | a Goffinet, André M4 aut |
700 | 1 | a Hall, Randy A4 aut |
700 | 1 | a Hamann, Jörg4 aut |
700 | 1 | a Hartmann, Nicole4 aut |
700 | 1 | a Lin, Hsi-Hsien4 aut |
700 | 1 | a Liu, Mingyao4 aut |
700 | 1 | a Luo, Rong4 aut |
700 | 1 | a Mogha, Amit4 aut |
700 | 1 | a Monk, Kelly R4 aut |
700 | 1 | a Peeters, Miriam C4 aut |
700 | 1 | a Prömel, Simone4 aut |
700 | 1 | a Ressl, Susanne4 aut |
700 | 1 | a Schiöth, Helgi Bu Uppsala universitet,Funktionell farmakologi4 aut0 (Swepub:uu)helgschi |
700 | 1 | a Sigoillot, Séverine M4 aut |
700 | 1 | a Song, Helen4 aut |
700 | 1 | a Talbot, William S4 aut |
700 | 1 | a Tall, Gregory G4 aut |
700 | 1 | a White, James P4 aut |
700 | 1 | a Wolfrum, Uwe4 aut |
700 | 1 | a Xu, Lei4 aut |
700 | 1 | a Piao, Xianhua4 aut |
710 | 2 | a Uppsala universitetb Funktionell farmakologi4 org |
773 | 0 | t Annals of the New York Academy of Sciencesd : Wileyg 1333, s. 43-64q 1333<43-64x 0077-8923x 1749-6632 |
856 | 4 | u https://europepmc.org/articles/pmc4278406?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-238747 |
856 | 4 8 | u https://doi.org/10.1111/nyas.12580 |
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