Two separate plasma membrane Ca2+ carriers participate in receptor-mediated Ca2+ influx in rat hepatocytes.

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Fältnamn	Indikatorer	Metadata
000		03148naa a2200361 4500
001		oai:DiVA.org:uu-248132
003		SwePub
008		150327s1994 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2481322 URI
024	7	a https://doi.org/10.1016/0167-4889(94)90230-52 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kass, G E4 aut
245	1 0	a Two separate plasma membrane Ca2+ carriers participate in receptor-mediated Ca2+ influx in rat hepatocytes.
264	1	b Elsevier BV,c 1994
338		a print2 rdacarrier
520		a The plasma membrane Ca2+ carrier system involved in receptor-mediated Ca2+ entry was studied. Using the Ca2+ readdition protocol, the rate of cytosolic free Ca2+ concentration ([Ca2+]i) increase in vasopressin-pretreated hepatocytes was significantly higher than in thapsigargin- or 2,5-di(tert-butyl)hydroquinone-pretreated cells. The addition of Mn2+ to unstimulated hepatocytes resulted in a biphasic quench of fura-2 fluorescence. After an initial phase that was fast in rate but of short duration, the rate of fura-2 quench by Mn2+ became much slower and lasted until all the cellular fura-2 was quenched. Pretreatment of the cells with vasopressin only accelerated the rate of the latter phase but not of the initial one. In agonist-stimulated cells, acidification of the extracellular medium or the presence of ruthenium red, econazole or SK&F 96365 decreased the rates of both [Ca2+]i increase and Mn2+ entry upon addition of the respective cation. By contrast, neomycin and N-tosyl-L-phenylalanine chloromethyl ketone markedly decreased the rate of [Ca2+]i increase upon Ca2+ readdition but had no effect on vasopressin-stimulated Mn2+ entry. None of the treatments affected the ability of vasopressin and thapsigargin to mobilize the internal Ca2+ store. It is concluded that in hepatocytes the two pathways of receptor-mediated Ca2+ entry control two distinct yet pharmacologically related cation carriers.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskap0 (SwePub)3052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciences0 (SwePub)3052 hsv//eng
700	1	a Chow, S C4 aut
700	1	a Gahm, A4 aut
700	1	a Webb, Dominic-Lucu Rolf Luft Center for Diabetes Research, Department of Endocrinology, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:uu)domwe127
700	1	a Berggren, P O4 aut
700	1	a Llopis, J4 aut
700	1	a Orrenius, S4 aut
710	2	a Rolf Luft Center for Diabetes Research, Department of Endocrinology, Karolinska Institutet, Stockholm, Sweden4 org
773	0	t Biochimica et Biophysica Actad : Elsevier BVg 1223:2, s. 226-33q 1223:2<226-33x 0006-3002x 1878-2434
773	0	t Biochimica et Biophysica Acta (BBA) - Molecular Cell Researchd : Elsevier BVg 1223:2, s. 226-33q 1223:2<226-33x 0167-4889
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248132
856	4 8	u https://doi.org/10.1016/0167-4889(94)90230-5

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Av författaren/redakt...: Kass, G E; Chow, S C; Gahm, A; Webb, Dominic-Lu ...; Berggren, P O; Llopis, J; visa fler...; Orrenius, S; visa färre...

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