Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: onr:"swepub:oai:DiVA.org:uu-252379" > Age- and sex-specif...

1 av 1
Föregående post
Nästa post
Till träfflistan

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		08227naa a2201453 4500
001		oai:DiVA.org:uu-252379
003		SwePub
008		150506s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:29ecfaca-90ba-4ea2-a168-d6ee83b267a3
009		oai:prod.swepub.kib.ki.se:131119833
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2523792 URI
024	7	a https://doi.org/10.2337/db14-09882 DOI
024	7	a https://lup.lub.lu.se/record/51427622 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1311198332 URI
040		a (SwePub)uud (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Fall, Toveu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)tovfa878
245	1 0	a Age- and sex-specific causal effects of adiposity on cardiovascular risk factors
264		c 2015-02-23
264	1	b American Diabetes Association,c 2015
338		a print2 rdacarrier
500		a T.V. and S.H. contributed equally to this work.
520		a Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 × 10(-107)) and stratified analyses (all P < 3.3 × 10(-30)). We found evidence of a causal effect of adiposity on blood pressure, fasting levels of insulin, C-reactive protein, interleukin-6, HDL cholesterol, and triglycerides in a nonstratified analysis and in the <55-year stratum. Further, we found evidence of a smaller causal effect on total cholesterol (P for difference = 0.015) in the ≥55-year stratum than in the <55-year stratum, a finding that could be explained by biology, survival bias, or differential medication. In conclusion, this study extends previous knowledge of the effects of adiposity by providing sex- and age-specific causal estimates on cardiovascular risk factors.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Hägg, Sarau Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)sarha464
700	1	a Ploner, Alexanderu Karolinska Institutet4 aut
700	1	a Mägi, Reedik4 aut
700	1	a Fischer, Krista4 aut
700	1	a Draisma, Harmen H M4 aut
700	1	a Sarin, Antti-Pekka4 aut
700	1	a Benyamin, Beben4 aut
700	1	a Ladenvall, Claesu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-cll
700	1	a Åkerlund, Mikaelu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)medk-mak
700	1	a Kals, Mart4 aut
700	1	a Esko, Tõnu4 aut
700	1	a Nilsson, Peteru Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)medf-pni
700	1	a Kaakinen, Marika4 aut
700	1	a Huikari, Ville4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Meirhaeghe, Aline4 aut
700	1	a Kristiansson, Katiu Karolinska Institutet4 aut
700	1	a Nuotio, Marja-Liisa4 aut
700	1	a Kobl, Michael4 aut
700	1	a Grallert, Harald4 aut
700	1	a Dehghan, Abbas4 aut
700	1	a Kuningas, Maris4 aut
700	1	a de Vries, Paul S4 aut
700	1	a de Bruijn, Renée F A G4 aut
700	1	a Willems, Sara M4 aut
700	1	a Heikkilä, Kauko4 aut
700	1	a Silventoinen, Karri4 aut
700	1	a Pietiläinen, Kirsi H4 aut
700	1	a Legry, Vanessa4 aut
700	1	a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517
700	1	a Goumidi, Louisa4 aut
700	1	a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin4 aut0 (Swepub:uu)anncsyva
700	1	a Strauch, Konstantin4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Lichtner, Peter4 aut
700	1	a Herder, Christian4 aut
700	1	a Palotie, Aarno4 aut
700	1	a Menni, Cristina4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a Kuulasmaa, Kari4 aut
700	1	a Havulinna, Aki S4 aut
700	1	a Moreno, Luis A4 aut
700	1	a Gonzalez-Gross, Marcela4 aut
700	1	a Evans, Alun4 aut
700	1	a Tregouet, David-Alexandre4 aut
700	1	a Yarnell, John W G4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Ferrières, Jean4 aut
700	1	a Veronesi, Giovanni4 aut
700	1	a Perola, Markus4 aut
700	1	a Arveiler, Dominique4 aut
700	1	a Brambilla, Paolo4 aut
700	1	a Lind, Larsu Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind
700	1	a Kaprio, Jaakko4 aut
700	1	a Hofman, Albert4 aut
700	1	a Stricker, Bruno H4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Ikram, M Arfan4 aut
700	1	a Franco, Oscar H4 aut
700	1	a Cottel, Dominique4 aut
700	1	a Dallongeville, Jean4 aut
700	1	a Hall, Alistair S4 aut
700	1	a Jula, Antti4 aut
700	1	a Tobin, Martin D4 aut
700	1	a Penninx, Brenda W4 aut
700	1	a Peters, Annette4 aut
700	1	a Gieger, Christian4 aut
700	1	a Samani, Nilesh J4 aut
700	1	a Montgomery, Grant W4 aut
700	1	a Whitfield, John B4 aut
700	1	a Martin, Nicholas G4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Spector, Tim D4 aut
700	1	a Magnusson, Patrik K4 aut
700	1	a Amouyel, Philippe4 aut
700	1	a Boomsma, Dorret I4 aut
700	1	a Nilsson, Peter M4 aut
700	1	a Järvelin, Marjo-Riitta4 aut
700	1	a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
700	1	a Metspalu, Andres4 aut
700	1	a Strachan, David P4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Ripatti, Samuli4 aut
700	1	a Pedersen, Nancy L4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425
710	2	a Uppsala universitetb Molekylär epidemiologi4 org
773	0	t Diabetesd : American Diabetes Associationg 64:5, s. 1841-1852q 64:5<1841-1852x 0012-1797x 1939-327X
856	4	u https://diabetes.diabetesjournals.org/content/diabetes/64/5/1841.full.pdf
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/25712996?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.2337/db14-0988y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-252379
856	4 8	u https://doi.org/10.2337/db14-0988
856	4 8	u https://lup.lub.lu.se/record/5142762
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:131119833

Hitta via bibliotek

Diabetes (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Fall, Tove; Hägg, Sara; Ploner, Alexande ...; Mägi, Reedik; Fischer, Krista; Draisma, Harmen ...; visa fler...; Sarin, Antti-Pek ...; Benyamin, Beben; Ladenvall, Claes; Åkerlund, Mikael; Kals, Mart; Esko, Tõnu; Nilsson, Peter; Kaakinen, Marika; Huikari, Ville; Mangino, Massimo; Meirhaeghe, Alin ...; Kristiansson, Ka ...; Nuotio, Marja-Li ...; Kobl, Michael; Grallert, Harald; Dehghan, Abbas; Kuningas, Maris; de Vries, Paul S; de Bruijn, Renée ...; Willems, Sara M; Heikkilä, Kauko; Silventoinen, Ka ...; Pietiläinen, Kir ...; Legry, Vanessa; Giedraitis, Vilm ...; Goumidi, Louisa; Syvänen, Ann-Chr ...; Strauch, Konstan ...; Koenig, Wolfgang; Lichtner, Peter; Herder, Christia ...; Palotie, Aarno; Menni, Cristina; Uitterlinden, An ...; Kuulasmaa, Kari; Havulinna, Aki S; Moreno, Luis A; Gonzalez-Gross, ...; Evans, Alun; Tregouet, David- ...; Yarnell, John W ...; Virtamo, Jarmo; Ferrières, Jean; Veronesi, Giovan ...; Perola, Markus; Arveiler, Domini ...; Brambilla, Paolo; Lind, Lars; Kaprio, Jaakko; Hofman, Albert; Stricker, Bruno ...; van Duijn, Corne ...; Ikram, M Arfan; Franco, Oscar H; Cottel, Dominiqu ...; Dallongeville, J ...; Hall, Alistair S; Jula, Antti; Tobin, Martin D; Penninx, Brenda ...; Peters, Annette; Gieger, Christia ...; Samani, Nilesh J; Montgomery, Gran ...; Whitfield, John ...; Martin, Nicholas ...; Groop, Leif; Spector, Tim D; Magnusson, Patri ...; Amouyel, Philipp ...; Boomsma, Dorret ...; Nilsson, Peter M; Järvelin, Marjo- ...; Lyssenko, Valeri ...; Metspalu, Andres; Strachan, David ...; Salomaa, Veikko; Ripatti, Samuli; Pedersen, Nancy ...; Prokopenko, Inga; McCarthy, Mark I; Ingelsson, Erik; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

Artiklar i publikationen: Diabetes

Av lärosätet: Uppsala universitet; Lunds universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se