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The Shepherds' Tale :
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Forsberg, SimonSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
(author)
The Shepherds' Tale : A Genome-Wide Study across 9 Dog Breeds Implicates Two Loci in the Regulation of Fructosamine Serum Concentration in Belgian Shepherds
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-05-13
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Public Library of Science (PLoS),2015
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-256241
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256241URI
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https://doi.org/10.1371/journal.pone.0123173DOI
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https://res.slu.se/id/publ/68702URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated haemoglobin (HbA1c) are two major biomarkers of glycaemia, where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on chromosome 3 (rho(corrected) approximate to 1:68 x 10(-6)) in Belgian shepherd dogs of the Malinois subtype. The associated region and its close neighbourhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed specificity, we screened the genome for reduced heterozygosity stretches private to the Belgian shepherd breed. This revealed a region with reduced heterozygosity that shows a statistically significant interaction (rho = 0.025) with the association region on chromosome 3. This region also harbours some interesting candidate genes and regulatory regions but the exact mechanisms underlying the interaction are still unknown. Nevertheless, this finding provides a plausible explanation for breed-specific genetic effects for complex traits in dogs. Shepherd breeds are at low risk of developing diabetes mellitus. The findings in Belgian shepherds could be connected to a protective mechanism against the disease. Further insight into the regulation of glucose metabolism could improve diagnostic and therapeutic methods for diabetes mellitus.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kierczak, MarcinSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Uppsala University(Swepub:slu)49557
(author)
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Ljungvall, IngridSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)48949
(author)
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Merveille, Anne-Christine
(author)
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Gouni, Vassiliki
(author)
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Wiberg, Maria
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Willesen, Jakob Lundgren
(author)
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Hanås, SofiaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Evidensia Animal Clinic Västerås(Swepub:slu)109904
(author)
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Lequarre, Anne-Sophie
(author)
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Sorensen, Louise Mejer
(author)
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Tiret, Laurent
(author)
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McEntee, Kathleen
(author)
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Seppala, Eija
(author)
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Koch, Jorgen
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Battaille, Geraldine
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Lohi, Hannes
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Fredholm, Merete
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Chetboul, Valerie
(author)
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Häggström, JensSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)48327
(author)
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Carlborg, ÖrjanSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish University of Agricultural Sciences, Uppsala, Sweden(Swepub:slu)48083
(author)
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Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)kerli865
(author)
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Höglund, KatjaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB)(Swepub:slu)48365
(author)
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Sveriges lantbruksuniversitetInstitutionen för kliniska vetenskaper (KV)
(creator_code:org_t)
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Sveriges lantbruksuniversitet
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In:PLOS ONE: Public Library of Science (PLoS)10:51932-6203
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Forsberg, Simon
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Kierczak, Marcin
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Ljungvall, Ingri ...
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Merveille, Anne- ...
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Gouni, Vassiliki
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Wiberg, Maria
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Willesen, Jakob ...
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Hanås, Sofia
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Lequarre, Anne-S ...
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Sorensen, Louise ...
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Tiret, Laurent
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McEntee, Kathlee ...
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Seppala, Eija
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Koch, Jorgen
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Battaille, Geral ...
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Lohi, Hannes
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Fredholm, Merete
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Chetboul, Valeri ...
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Häggström, Jens
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Carlborg, Örjan
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Lindblad-Toh, Ke ...
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Höglund, Katja
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