Sökning: onr:"swepub:oai:DiVA.org:uu-258896" > Modulation of Genet...
Fältnamn | Indikatorer | Metadata |
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000 | 07712naa a2201753 4500 | |
001 | oai:DiVA.org:uu-258896 | |
003 | SwePub | |
008 | 150721s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2588962 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.01197522 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Huffman, Jennifer E.4 aut |
245 | 1 0 | a Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans |
264 | c 2015-03-26 | |
264 | 1 | b Public Library of Science (PLoS),c 2015 |
338 | a electronic2 rdacarrier | |
520 | a We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, P-inter= 2.6 x 10(-8)). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDAR-ADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10(-8)), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10(-8)), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10(-4)). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Albrecht, Eva4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Kapur, Karen4 aut |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Kutalik, Zoltn4 aut |
700 | 1 | a Pirastu, Nicola4 aut |
700 | 1 | a Pistis, Giorgio4 aut |
700 | 1 | a Lopez, Lorna M.4 aut |
700 | 1 | a Haller, Toomas4 aut |
700 | 1 | a Salo, Perttu4 aut |
700 | 1 | a Goel, Anuj4 aut |
700 | 1 | a Li, Man4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Dehghan, Abbas4 aut |
700 | 1 | a Ruggiero, Daniela4 aut |
700 | 1 | a Malerba, Giovanni4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a Nolte, Ilja M.4 aut |
700 | 1 | a Portas, Laura4 aut |
700 | 1 | a Phipps-Green, Amanda4 aut |
700 | 1 | a Boteva, Lora4 aut |
700 | 1 | a Navarro, Pau4 aut |
700 | 1 | a Johansson, Åsau Uppsala universitet,Medicinsk genetik och genomik,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)asjoh108 |
700 | 1 | a Hicks, Andrew A.4 aut |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Esko, Tonu4 aut |
700 | 1 | a Peden, John F.4 aut |
700 | 1 | a Harris, Sarah E.4 aut |
700 | 1 | a Murgia, Federico4 aut |
700 | 1 | a Wild, Sarah H.4 aut |
700 | 1 | a Tenesa, Albert4 aut |
700 | 1 | a Tin, Adrienne4 aut |
700 | 1 | a Mihailov, Evelin4 aut |
700 | 1 | a Grotevendt, Anne4 aut |
700 | 1 | a Gislason, Gauti K.4 aut |
700 | 1 | a Coresh, Josef4 aut |
700 | 1 | a D'Adamo, Pio4 aut |
700 | 1 | a Ulivi, Sheila4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Waeber, Gerard4 aut |
700 | 1 | a Campbell, Susan4 aut |
700 | 1 | a Kolcic, Ivana4 aut |
700 | 1 | a Fisher, Krista4 aut |
700 | 1 | a Viigimaa, Margus4 aut |
700 | 1 | a Metter, Jeffrey E.4 aut |
700 | 1 | a Masciullo, Corrado4 aut |
700 | 1 | a Trabetti, Elisabetta4 aut |
700 | 1 | a Bombieri, Cristina4 aut |
700 | 1 | a Sorice, Rossella4 aut |
700 | 1 | a Doering, Angela4 aut |
700 | 1 | a Reischl, Eva4 aut |
700 | 1 | a Strauch, Konstantin4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Waldenberger, Melanie4 aut |
700 | 1 | a Wichmann, H-Erich4 aut |
700 | 1 | a Davies, Gail4 aut |
700 | 1 | a Gow, Alan J.4 aut |
700 | 1 | a Dalbeth, Nicola4 aut |
700 | 1 | a Stamp, Lisa4 aut |
700 | 1 | a Smit, Johannes H.4 aut |
700 | 1 | a Kirin, Mirna4 aut |
700 | 1 | a Nagaraja, Ramaiah4 aut |
700 | 1 | a Nauck, Matthias4 aut |
700 | 1 | a Schurmann, Claudia4 aut |
700 | 1 | a Budde, Kathrin4 aut |
700 | 1 | a Farrington, Susan M.4 aut |
700 | 1 | a Theodoratou, Evropi4 aut |
700 | 1 | a Jula, Antti4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Sala, Cinzia4 aut |
700 | 1 | a Hengstenberg, Christian4 aut |
700 | 1 | a Burnier, Michel4 aut |
700 | 1 | a Maegi, Reedik4 aut |
700 | 1 | a Klopp, Norman4 aut |
700 | 1 | a Kloiber, Stefan4 aut |
700 | 1 | a Schipf, Sabine4 aut |
700 | 1 | a Ripatti, Samuli4 aut |
700 | 1 | a Cabras, Stefano4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a Homuth, Georg4 aut |
700 | 1 | a Nutile, Teresa4 aut |
700 | 1 | a Munroe, Patricia B.4 aut |
700 | 1 | a Hastie, Nicholas4 aut |
700 | 1 | a Campbell, Harry4 aut |
700 | 1 | a Rudan, Igor4 aut |
700 | 1 | a Cabrera, Claudia4 aut |
700 | 1 | a Haley, Chris4 aut |
700 | 1 | a Franco, Oscar H.4 aut |
700 | 1 | a Merriman, Tony R.4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Pirastu, Mario4 aut |
700 | 1 | a Penninx, Brenda W.4 aut |
700 | 1 | a Snieder, Harold4 aut |
700 | 1 | a Metspalu, Andres4 aut |
700 | 1 | a Ciullo, Marina4 aut |
700 | 1 | a Pramstaller, Peter P.4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Gambaro, Giovanni4 aut |
700 | 1 | a Deary, Ian J.4 aut |
700 | 1 | a Dunlop, Malcolm G.4 aut |
700 | 1 | a Wilson, James F.4 aut |
700 | 1 | a Gasparini, Paolo4 aut |
700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Medicinsk genetik och genomik4 aut0 (Swepub:uu)ulfgyll |
700 | 1 | a Spector, Tim D.4 aut |
700 | 1 | a Wright, Alan F.4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Perola, Markus4 aut |
700 | 1 | a Bochud, Murielle4 aut |
700 | 1 | a Kao, W. H. Linda4 aut |
700 | 1 | a Caulfield, Mark4 aut |
700 | 1 | a Toniolo, Daniela4 aut |
700 | 1 | a Voelzke, Henry4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Koettgen, Anna4 aut |
700 | 1 | a Vitart, Veronique4 aut |
710 | 2 | a Uppsala universitetb Medicinsk genetik och genomik4 org |
773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 10:3q 10:3x 1932-6203 |
856 | 4 | u https://doi.org/10.1371/journal.pone.0119752y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:842630/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1371/journal.pone.0119752 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258896 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0119752 |
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