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History of Maternal...
History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring : Differentials by Miscarriage or Stillbirth History and Disease Subtype.
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- Karalexi, M A (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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- Skalkidou, Alkistis, 1977- (author)
- Uppsala universitet,Obstetrik & gynekologi,Reproduktiv hälsa/Sundström Poromaa
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- Thomopoulos, T P (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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- Belechri, M (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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- Biniaris-Georgallis, S-I (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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- Bouka, E (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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- Baka, M (author)
- Department of Pediatric Hematology-Oncology, 'Pan. & Agl. Kyriakou' Children's Hospital, Athens, Greece
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- Hatzipantelis, E (author)
- 2nd Department of Pediatrics, Aristotelion University of Thessaloniki, AHEPA General Hospital, Greece
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- Kourti, M (author)
- Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki, Greece
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- Polychronopoulou, S (author)
- Department of Pediatric Haematology-Oncology, 'Aghia Sophia' Children's Hospital, Athens, Greece
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- Sidi, V (author)
- Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki, Greece
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- Stiakaki, E (author)
- Department of Pediatric Hematology-Oncology, University Hospital of Heraklion, Greece
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- Moschovi, M (author)
- Haematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, 'Aghia Sophia' Children's Hospital, Greece
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- Dessypris, N (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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- Petridou, E Th (author)
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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(creator_code:org_t)
- 2015-07-14
- 2015
- English.
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In: Paediatric and Perinatal Epidemiology. - : Wiley. - 0269-5022 .- 1365-3016. ; 29:5, s. 453-61
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Despite the putative intrauterine origins of childhood (0-14 years) leukaemia, it is complex to assess the impact of perinatal factors on disease onset. Results on the association of maternal history of fetal loss (miscarriage/stillbirth) with specific disease subtypes in the subsequent offspring are in conflict. We sought to investigate whether miscarriage and stillbirth may have different impacts on the risk of acute lymphoblastic leukaemia (ALL) and of its main immunophenotypes (B-cell and T-cell ALL), as contrasted to acute myeloid leukaemia (AML).METHODS: One thousand ninety-nine ALL incidents (957 B-ALL) and 131 AML cases along with 1:1 age and gender-matched controls derived from the Nationwide Registry for Childhood Hematological Malignancies and Brain Tumors (1996-2013) were studied. Multivariable regression models were used to assess the roles of previous miscarriage(s) and stillbirth(s) on ALL (overall, B-, T-ALL) and AML, controlling for potential confounders.RESULTS: Statistically significant exposure and disease subtype-specific associations of previous miscarriage(s) exclusively with AML [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.00, 2.81] and stillbirth(s) with ALL [OR 4.82, 95% CI 1.63, 14.24] and B-ALL particularly, emerged.CONCLUSION: Differential pathophysiological pathways pertaining to genetic polymorphisms or cytogenetic aberrations are likely to create hostile environments leading either to fetal loss or the development of specific leukaemia subtypes in subsequent offspring, notably distinct associations of maternal miscarriage history confined to AML and stillbirth history confined to ALL (specifically B-ALL). If confirmed and further supported by studies revealing underlying mechanisms, these results may shed light on the divergent leukemogenesis processes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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- By the author/editor
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Karalexi, M A
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Skalkidou, Alkis ...
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Thomopoulos, T P
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Belechri, M
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Biniaris-Georgal ...
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Bouka, E
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Baka, M
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Hatzipantelis, E
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Kourti, M
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Polychronopoulou ...
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Sidi, V
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Stiakaki, E
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Moschovi, M
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Dessypris, N
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Petridou, E Th
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Paediatric and P ...
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Uppsala University