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Sökning: onr:"swepub:oai:DiVA.org:uu-263430" > A novel multi-tissu...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005508naa a2200553 4500
001oai:DiVA.org:uu-263430
003SwePub
008150930s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:131921700
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2634302 URI
0247 a https://doi.org/10.1186/s13059-015-0750-x2 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1319217002 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Sood, Sanjanau XRGenomics Ltd, London, England.;Kings Coll London, Div Genet & Mol Med, Guys Hosp, London SE1 9RT, England.4 aut
2451 0a A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
264 c 2015-09-07
264 1b Springer Science and Business Media LLC,c 2015
338 a electronic2 rdacarrier
520 a Background: Diagnostics of the human ageing process may help predict future healthcare needs or guide preventative measures for tackling diseases of older age. We take a transcriptomics approach to build the first reproducible multi-tissue RNA expression signature by gene-chip profiling tissue from sedentary normal subjects who reached 65 years of age in good health. Results: One hundred and fifty probe-sets form an accurate classifier of young versus older muscle tissue and this healthy ageing RNA classifier performed consistently in independent cohorts of human muscle, skin and brain tissue (n = 594, AUC = 0.83-0.96) and thus represents a biomarker for biological age. Using the Uppsala Longitudinal Study of Adult Men birth-cohort (n = 108) we demonstrate that the RNA classifier is insensitive to confounding lifestyle biomarkers, while greater gene score at age 70 years is independently associated with better renal function at age 82 years and longevity. The gene score is 'up-regulated' in healthy human hippocampus with age, and when applied to blood RNA profiles from two large independent age-matched dementia case-control data sets (n = 717) the healthy controls have significantly greater gene scores than those with cognitive impairment. Alone, or when combined with our previously described prototype Alzheimer disease (AD) RNA 'disease signature', the healthy ageing RNA classifier is diagnostic for AD. Conclusions: We identify a novel and statistically robust multi-tissue RNA signature of human healthy ageing that can act as a diagnostic of future health, using only a peripheral blood sample. This RNA signature has great potential to assist research aimed at finding treatments for and/or management of AD and other ageing-related conditions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng
7001 a Gallagher, Iain J.u XRGenomics Ltd, London, England.;Univ Stirling, Sch Hlth, Stirling FK9 4LA, Scotland.4 aut
7001 a Lunnon, Katieu Kings Coll London, Dept Old Age Psychiat, London SE1 9RT, England.4 aut
7001 a Rullman, Ericu Karolinska Institutet,Karolinska Univ Hosp, Div Clin Physiol, Stockholm, Sweden.4 aut
7001 a Keohane, Aoifeu Kings Coll London, Dept Old Age Psychiat, London SE1 9RT, England.4 aut
7001 a Crossland, Hannahu Kings Coll London, Div Genet & Mol Med, Guys Hosp, London SE1 9RT, England.;Derby Royal Hosp, Sch Med, Derby, England.4 aut
7001 a Phillips, Bethan E.u Derby Royal Hosp, Sch Med, Derby, England.4 aut
7001 a Cederholm, Tommyu Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)tomce419
7001 a Jensen, Thomasu Med Prognosis Inst AS, Horsholm, Denmark.4 aut
7001 a van Loon, Luc J. C.u Maastricht Univ, NUTRIM, Maastricht, Netherlands.4 aut
7001 a Lannfelt, Larsu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)lalan021
7001 a Kraus, William E.u Duke Univ, Sch Med, Duke Mol Physiol Inst, Durham, NC USA.4 aut
7001 a Atherton, Philip J.u Derby Royal Hosp, Sch Med, Derby, England.4 aut
7001 a Howard, Robertu Kings Coll London, Dept Old Age Psychiat, London SE1 9RT, England.4 aut
7001 a Gustafsson, Thomasu Karolinska Institutet,Karolinska Univ Hosp, Div Clin Physiol, Stockholm, Sweden.4 aut
7001 a Hodges, Angelau Kings Coll London, Dept Old Age Psychiat, London SE1 9RT, England.4 aut
7001 a Timmons, James A.u XRGenomics Ltd, London, England.;Kings Coll London, Div Genet & Mol Med, Guys Hosp, London SE1 9RT, England.4 aut
7102 a XRGenomics Ltd, London, England.;Kings Coll London, Div Genet & Mol Med, Guys Hosp, London SE1 9RT, England.b XRGenomics Ltd, London, England.;Univ Stirling, Sch Hlth, Stirling FK9 4LA, Scotland.4 org
7730 t Genome Biologyd : Springer Science and Business Media LLCg 16q 16x 1465-6906x 1474-760X
8564 u https://doi.org/10.1186/s13059-015-0750-xy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:859567/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-015-0750-x
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-263430
8564 8u https://doi.org/10.1186/s13059-015-0750-x
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:131921700

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