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Sökning: onr:"swepub:oai:DiVA.org:uu-265922" > E-cadherin can limi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005975naa a2200697 4500
001oai:DiVA.org:uu-265922
003SwePub
008151104s2015 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2659222 URI
0247 a https://doi.org/10.15252/embj.2015917392 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Huels, David J.u Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.4 aut
2451 0a E-cadherin can limit the transforming properties of activating beta-catenin mutations
264 c 2015-08-03
264 1b EMBO,c 2015
338 a print2 rdacarrier
520 a Wnt pathway deregulation is a common characteristic of many cancers. Only colorectal cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of the pancreas) have activating mutations in beta-catenin (CTNNB1). We have compared the dynamics and the potency of beta-catenin mutations in vivo. Within the murine small intestine (SI), an activating mutation of beta-catenin took much longer to achieve Wnt deregulation and acquire a crypt-progenitor cell (CPC) phenotype than Apc or Gsk3 loss. Within the colon, a single activating mutation of beta-catenin was unable to drive Wnt deregulation or induce the CPC phenotype. This ability of beta-catenin mutation to differentially transform the SI versus the colon correlated with higher expression of E-cadherin and a higher number of E-cadherin: beta-catenin complexes at the membrane. Reduction in E-cadherin synergised with an activating mutation of beta-catenin resulting in a rapid CPC phenotype within the SI and colon. Thus, there is a threshold of beta-catenin that is required to drive transformation, and E-cadherin can act as a buffer to sequester mutated beta-catenin.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653 a APC
653 a beta-catenin
653 a colorectal cancer
653 a E-cadherin
7001 a Ridgway, Rachel A.u Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.4 aut
7001 a Radulescu, Sorinau Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.4 aut
7001 a Leushacke, Marcu ASTAR, Inst Med Biol, Singapore, Singapore.4 aut
7001 a Campbell, Andrew D.u Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.4 aut
7001 a Biswas, Sujatau Univ Oxford, Wellcome Trust Ctr Human Genet, Gastrointestinal Stem Cell Biol Lab, Oxford, England.;John Radcliffe Hosp, Nuffield Dept Clin Med, Div Expt Med, Translat Gastroenterol Unit, Oxford OX3 9DU, Headington, England.4 aut
7001 a Leedham, Simonu Univ Oxford, Wellcome Trust Ctr Human Genet, Gastrointestinal Stem Cell Biol Lab, Oxford, England.;John Radcliffe Hosp, Nuffield Dept Clin Med, Div Expt Med, Translat Gastroenterol Unit, Oxford OX3 9DU, Headington, England.4 aut
7001 a Serra, Stefanou Univ Hlth Network, Toronto Med Labs, Dept Pathol, Toronto, ON, Canada.4 aut
7001 a Chetty, Runjanu Univ Hlth Network, Toronto Med Labs, Dept Pathol, Toronto, ON, Canada.4 aut
7001 a Moreaux, Guenievreu Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.4 aut
7001 a Parry, Leeu Cardiff Univ, European Canc Stem Cell Res Inst, Cardiff CF10 3AX, S Glam, Wales.4 aut
7001 a Matthews, Jamesu Cardiff Univ, European Canc Stem Cell Res Inst, Cardiff CF10 3AX, S Glam, Wales.4 aut
7001 a Song, Feiu Univ Giessen, Inst Physiol, D-35390 Giessen, Germany.4 aut
7001 a Hedley, Annu Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.4 aut
7001 a Kalna, Gabrielau Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.4 aut
7001 a Ceteci, Fatihu Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.4 aut
7001 a Reed, Karen R.u Cardiff Univ, European Canc Stem Cell Res Inst, Cardiff CF10 3AX, S Glam, Wales.4 aut
7001 a Meniel, Valerie S.u Cardiff Univ, European Canc Stem Cell Res Inst, Cardiff CF10 3AX, S Glam, Wales.4 aut
7001 a Maguire, Aoifeu St James Hosp, Trinity Coll Dublin, Dept Histopathol, Dublin 8, Ireland.4 aut
7001 a Doyle, Brendanu Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.;St James Hosp, Trinity Coll Dublin, Dept Histopathol, Dublin 8, Ireland.4 aut
7001 a Soderberg, Olau Uppsala universitet,Molekylära verktyg4 aut0 (Swepub:uu)olasoder
7001 a Barker, Nicku ASTAR, Inst Med Biol, Singapore, Singapore.4 aut
7001 a Watson, Alastairu Univ E Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England.4 aut
7001 a Larue, Lionelu Inst Curie, CNRS UMR3347, INSERM, U1021,Equipe Labellisee Ligue Natl Canc, F-91405 Orsay, France.4 aut
7001 a Clarke, Alan R.u Cardiff Univ, European Canc Stem Cell Res Inst, Cardiff CF10 3AX, S Glam, Wales.4 aut
7001 a Sansom, Owen J.u Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.4 aut
7102 a Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland.b ASTAR, Inst Med Biol, Singapore, Singapore.4 org
7730 t EMBO Journald : EMBOg 34:18, s. 2321-2333q 34:18<2321-2333x 0261-4189x 1460-2075
8564 u https://doi.org/10.15252/embj.201591739y Fulltext
8564 u http://emboj.embopress.org/content/34/18/2321y Fulltext
8564 u https://doi.org/10.15252/embj.201591739
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265922
8564 8u https://doi.org/10.15252/embj.201591739

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