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Sökning: onr:"swepub:oai:DiVA.org:uu-266453" > Managing synchronou...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003931naa a2200481 4500
001oai:DiVA.org:uu-266453
003SwePub
008151110s2015 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2664532 URI
0247 a https://doi.org/10.1016/j.ctrv.2015.06.0062 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Adam, René4 aut
2451 0a Managing synchronous liver metastases from colorectal cancer :b A multidisciplinary international consensus
264 1b Elsevier BV,c 2015
338 a electronic2 rdacarrier
520 a An international panel of multidisciplinary experts convened to develop recommendations for managing patients with colorectal cancer (CRC) and synchronous liver metastases (CRCLM). A modified Delphi method was used. CRCLM is defined as liver metastases detected at or before diagnosis of the primary CRC. Early and late metachronous metastases are defined as those detected ⩽12months and >12months after surgery, respectively. To provide information on potential curability, use of high-quality contrast-enhanced computed tomography (CT) before chemotherapy is recommended. Magnetic resonance imaging is increasingly being used preoperatively to aid detection of subcentimetric metastases, and alongside CT in difficult situations. To evaluate operability, radiology should provide information on: nodule size and number, segmental localization and relationship with major vessels, response after neoadjuvant chemotherapy, non-tumoral liver condition and anticipated remnant liver volume. Pathological evaluation should assess response to preoperative chemotherapy for both the primary tumour and metastases, and provide information on the tumour, margin size and micrometastases. Although the treatment strategy depends on the clinical scenario, the consensus was for chemotherapy before surgery in most cases. When the primary CRC is asymptomatic, liver surgery may be performed first (reverse approach). When CRCLM are unresectable, the goal of preoperative chemotherapy is to downsize tumours to allow resection. Hepatic resection should not be denied to patients with stable disease after optimal chemotherapy, provided an adequate liver remnant with inflow and outflow preservation remains. All patients with synchronous CRCLM should be evaluated by a hepatobiliary multidisciplinary team.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Colorectal cancer; Multidisciplinary team management; Surgery; Synchronous colorectal liver metastases; Systemic therapy
7001 a de Gramont, Aimery4 aut
7001 a Figueras, Joan4 aut
7001 a Kokudo, Norihiro4 aut
7001 a Kunstlinger, Francis4 aut
7001 a Loyer, Evelyne4 aut
7001 a Poston, Graeme4 aut
7001 a Rougier, Philippe4 aut
7001 a Rubbia-Brandt, Laura4 aut
7001 a Sobrero, Alberto4 aut
7001 a Teh, Catherine4 aut
7001 a Tejpar, Sabine4 aut
7001 a Van Cutsem, Eric4 aut
7001 a Vauthey, Jean-Nicolas4 aut
7001 a Påhlman, Larsu Uppsala universitet,Kolorektalkirurgi4 aut0 (Swepub:uu)larspahl
7102 a Uppsala universitetb Kolorektalkirurgi4 org
7730 t Cancer Treatment Reviewsd : Elsevier BVg 41:9, s. 729-741q 41:9<729-741x 0305-7372x 1532-1967
8564 u https://uu.diva-portal.org/smash/get/diva2:868262/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://www.cancertreatmentreviews.com/article/S0305737215001280/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-266453
8564 8u https://doi.org/10.1016/j.ctrv.2015.06.006

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