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FältnamnIndikatorerMetadata
00014586naa a2201057 4500
001oai:DiVA.org:uu-269285
003SwePub
008151215s2015 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:cb16c0d2-7d1f-422b-a45a-4782a9aa5155
009oai:DiVA.org:liu-123165
009oai:prod.swepub.kib.ki.se:132387554
009oai:DiVA.org:umu-112288
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2692852 URI
0247 a https://doi.org/10.1161/JAHA.115.0018532 DOI
0247 a https://lup.lub.lu.se/record/78409662 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1231652 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1323875542 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1122882 URI
040 a (SwePub)uud (SwePub)lud (SwePub)liud (SwePub)kid (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Persson, Jonasu Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.4 aut
2451 0a Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease
264 1b WILEY-BLACKWELL,c 2015
338 a electronic2 rdacarrier
500 a Funding: IMPROVE was supported by the European Commission (Contract number: QLG1-CT-2002-00896), the Swedish Heart-Lung Foundation, the Swedish Research Council (projects 8691 and 0593), the Knut and Alice Wallenberg Foundation, the Foundation for Strategic Research, the Stockholm County Council (project 592229), the Strategic Cardiovascular and Diabetes Programmes of Karolinska Institutet and Stockholm County Council, the European Union Framework Programme 7 (FP7/2007-2013) for the Innovative Medicine Initiative under grant agreement no. IMI/115006 (the SUMMIT consortium), the Academy of Finland (Grant #110413), the British Heart Foundation (RG2008/08, RG2008/014) and the Italian Ministry of Health (Ricerca Corrente). The SNP Technology Platform is supported by Uppsala University, Uppsala University Hospital and the Swedish Research Council for Infrastructures. Persson is supported by the Stockholm County Council (clinical postdoctorial appointment). Strawbridge is supported by Swedish Heart-Lung Foundation (20120600), the Tore Nilsson, Gamla Tjanarinnor and Thurings foundations. Gertow acknowledges support from the Swedish Heart-Lung Foundation and Stiftelsen for Gamla Tjanarinnor. Sabater-Lleal is supported by the Swedish Heart-Lung Foundation (20130399), and acknowledges funding from Ake Wiberg and Tore Nilssons foundations. Sennblad acknowledges funding from the Magnus Bergvall Foundation and the Foundation for Old Servants. Rauramaa acknowledges the Ministry of Education and Culture in Finland. S.So. is supported by the Vasterbotten County Council (ALF) and the Swedish Heart and Lung Foundation. AGT is supported by TAMOP 4.2.4.A/1-11-1-2012-0001 National Excellence Program - research fellowship co-financed by the European Union and the European Social Fund. M.K. is supported by the UK Medical Research Council (K013351), the Economic and Social Research Council and the Academy of Finland. The University College London Genetics Institute supported S.Sh.
500 a Funding Agencies|European Commission [QLG1-CT-2002-00896]; Swedish Heart-Lung Foundation; Swedish Research Council [8691, 0593]; Knut and Alice Wallenberg Foundation; Foundation for Strategic Research; Stockholm County Council [592229]; Karolinska Institutet; Stockholm County Council; European Union Framework Programme 7 for the Innovative Medicine Initiative [IMI/115006]; Academy of Finland [110413]; British Heart Foundation [RG2008/08, RG2008/014]; Italian Ministry of Health (Ricerca Corrente); Uppsala University; Uppsala University Hospital; Swedish Research Council for Infrastructures; Swedish Heart-Lung Foundation [20120600, 20130399]; Tore Nilsson foundation; Gamla Tjanarinnor foundation; Thurings foundation; Stiftelsen for Gamla Tjanarinnor; Ake Wiberg foundation; Tore Nilssons foundation; Magnus Bergvall Foundation; Foundation for Old Servants; Ministry of Education and Culture in Finland; Vasterbotten County Council; Swedish Heart and Lung Foundation; National Excellence Program [TAMOP 4.2.4.A/1-11-1-2012-0001]; European Union; European Social Fund; UK Medical Research Council [K013351]; Economic and Social Research Council; Academy of Finland; University College London Genetics Institute
520 a Background-Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT. Methods and Results-Baseline plasma adiponectin concentrationwas tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (beta=-0.018, P<0.001) in men but not in women (beta=-0.006, P=0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (beta=-0.0022, P=0.047), whereas no association was seen in women (0.0007, P=0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82,95% CI0.54 to 1.25). Agenescore of adiponectin-raisingalleles in6loci, reported recently inalarge multi-ethnic metaanalysis, was inversely associated with baseline mean bifurcation IMT in men (beta=-0.0008, P=0.004) but not in women (beta=-0.0003, P=0.522; P for interaction=0.007). Conclusions-This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a adiponectin
653 a atherosclerosis
653 a carotid intima-media thickness
653 a genetics
653 a Mendelian randomization
7001 a Strawbridge, Rona J.u Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.4 aut
7001 a McLeod, Olgau Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.,Karolinska Institute, Sweden4 aut
7001 a Gertow, Karlu Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.4 aut
7001 a Silveira, Angelau Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.4 aut
7001 a Baldassarre, Damianou Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy4 aut
7001 a Van Zuydam, Natalieu Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland4 aut
7001 a Shah, Soniau UCL, Genet Inst, London, England.;Univ Queensland, Diamantina Inst, Brisbane, Qld 4072, Australia.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.,UCL, England; University of Queensland, Australia; University of Queensland, Australia4 aut
7001 a Fava, Cristianou Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden; University of Verona, Italy,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.;Univ Verona, Hosp Policlin GB Rossi, Dept Med, Div Internal Med C, I-37100 Verona, Italy.4 aut0 (Swepub:lu)endo-cfa
7001 a Gustafsson, Stefanu Uppsala universitet,Molekylär epidemiologi,Uppsala University, Sweden4 aut0 (Swepub:uu)stegu732
7001 a Veglia, Fabriziou Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy4 aut
7001 a Sennblad, Bengtu Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Inst, Sci Life Lab, Stockholm, Sweden.4 aut
7001 a Larsson, Malinu Linköpings universitet,Bioinformatik,Tekniska fakulteten,Linkoping Univ, IFM Bioinformat, Linkoping, Sweden.4 aut0 (Swepub:liu)malla74
7001 a Sabater-Lleal, Mariau Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.4 aut
7001 a Leander, Karinu Karolinska Institutet4 aut
7001 a Gigante, Brunau Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.;Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.4 aut
7001 a Tabak, Adamu Semmelweis Univ, Fac Med, Dept Med 1, H-1085 Budapest, Hungary.,Semmelweis University, Hungary4 aut
7001 a Kivimaki, Mikau UCL, Dept Epidemiol & Publ Hlth, London, England.4 aut
7001 a Kauhanen, Jussiu Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.,University of Eastern Finland, Finland4 aut
7001 a Rauramaa, Raineru Kuopio Res Inst Exercise Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland.,Kuopio Research Institute Exercise Med, Finland; Kuopio University Hospital, Finland4 aut
7001 a Smit, Andries J.u Univ Groningen, Univ Med Ctr Groningen, Dept Med, NL-9700 AB Groningen, Netherlands.,University of Groningen, Netherlands4 aut
7001 a Mannarino, Elmou Univ Perugia, Dept Clin & Expt Med, Internal Med Angiol & Arteriosclerosis Dis, I-06100 Perugia, Italy.,University of Perugia, Italy4 aut
7001 a Giral, Philippeu Grp Hosp Pitie Salpetriere, AP HP, Serv Endocrinol Metab, Unites Prevent Cardiovasc, F-75634 Paris, France.,Grp Hospital Pitie Salpetriere, France4 aut
7001 a Humphries, Steve E.u UCL, Ctr Cardiovasc Genet, London, England.4 aut
7001 a Tremoli, Elenau Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy4 aut
7001 a de Faire, Ulfu Karolinska Institutet,Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.4 aut
7001 a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Sweden4 aut0 (Swepub:uu)larslind
7001 a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Uppsala University, Sweden4 aut0 (Swepub:uu)ering425
7001 a Hedblad, Bou Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.4 aut0 (Swepub:lu)medf-bhe
7001 a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.4 aut0 (Swepub:lu)endo-ome
7001 a Kumari, Meenau UCL, Genet Epidemiol Grp, Dept Epidemiol & Publ Hlth, London, England.4 aut
7001 a Hingorani, Aroonu Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;UCL, Genet Epidemiol Grp, Dept Epidemiol & Publ Hlth, London, England.,Karolinska Institute, Sweden; UCL, England4 aut
7001 a Morris, Andrew D.u Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland4 aut
7001 a Palmer, Colin N. A.u Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland4 aut
7001 a Lundman, Piau Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.4 aut
7001 a Ohrvik, Johnu Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.,Karolinska Institute, Sweden4 aut
7001 a Söderberg, Stefanu Umeå universitet,Kardiologi,Umea Univ, Dept Publ Hlth & Clin Med, Div Med, S-90187 Umea, Sweden.4 aut0 (Swepub:umu)stso0001
7001 a Hamsten, Anders4 aut
7102 a Karolinska Institutetb Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.4 org
7730 t Journal of the American Heart Associationd : WILEY-BLACKWELLg 4:8q 4:8x 2047-9980
8564 u https://doi.org/10.1161/JAHA.115.001853y Fulltext
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8564 u https://portal.research.lu.se/files/3573602/8611673x primaryx freey FULLTEXT
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8564 u http://dx.doi.org/10.1161/JAHA.115.001853x freey FULLTEXT
8564 u https://liu.diva-portal.org/smash/get/diva2:877379/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
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8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-123165
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132387554
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-112288

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