Sökning: onr:"swepub:oai:DiVA.org:uu-273975" > Serum adiponectin c...
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000 | 03442naa a2200373 4500 | |
001 | oai:DiVA.org:uu-273975 | |
003 | SwePub | |
008 | 160119s2004 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2739752 URI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mantzoros, Christos4 aut |
245 | 1 0 | a Serum adiponectin concentrations in relation to maternal and perinatal characteristics in newborns. |
264 | 1 | c 2004 |
338 | a print2 rdacarrier | |
520 | a OBJECTIVE: To assess serum adiponectin levels of neonates in relation to ponderal index and birth length with and without adjustment for potential confounding factors including maternal factors and perinatal characteristics.DESIGN: A cross-sectional study.METHODS: Three hundred and three newborns (Caucasian, singleton, full term, with a birth weight of > or =2500 g, and apparently healthy) were included in the study. Blood samples were collected from the newborns no later than the fifth day of life for measurements of adiponectin and major IGF system components (IGF-I, IGF-II, IGF binding protein-3 (IGFBP-3)). The data were analyzed using simple and multiple regression analyses.RESULTS: Adiponectin is substantially higher in neonates than in adults, with no evidence of the gender dimorphism observed among adults. We found an inverse association between neonatal adiponectin levels and newborn ponderal index and a positive association with newborn length by univariate analysis. We also found a statistically significant inverse association of adiponectin with jaundice/bilirubin, and a marginally significant positive association of this hormone with IGFBP-3 but no significant association with any maternal factors. In multivariate analysis, the inverse association between serum adiponectin and ponderal index does not remain significant after adjustment for potential confounding factors. In contrast, neonatal adiponectin levels correlate inversely significantly and independently with liver maturity and IGF-II and tend to remain positively associated with IGFBP-3 and increased birth length.CONCLUSIONS: An inverse association of adiponectin with ponderal index by univariate analysis is not independent from confounding factors. In contrast, the positive association between serum adiponectin and birth length may reflect either a direct effect of adiponectin or an adiponectin-mediated increase in the sensitivity of tissues to insulin and components of the IGF system, and needs to be explored further. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Petridou, Eleni4 aut |
700 | 1 | a Alexe, Delia-Marina4 aut |
700 | 1 | a Skalkidou, Alkistis4 aut |
700 | 1 | a Dessypris, Nick4 aut |
700 | 1 | a Papathoma, Eugenia4 aut |
700 | 1 | a Salvanos, Heraklis4 aut |
700 | 1 | a Shetty, Greeshma4 aut |
700 | 1 | a Gavrila, Alina4 aut |
700 | 1 | a Kedikoglou, Simos4 aut |
700 | 1 | a Chrousos, George4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
773 | 0 | t European Journal of Endocrinologyg 151:6q 151:6x 0804-4643x 1479-683X |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273975 |
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