Sökning: onr:"swepub:oai:DiVA.org:uu-274647" > Associations of Bod...
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000 | 03697naa a2200373 4500 | |
001 | oai:DiVA.org:uu-274647 | |
003 | SwePub | |
008 | 160125s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2746472 URI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kumar, Jitender4 aut |
245 | 1 0 | a Associations of Body Mass Index and Obesity-Related Genetic Variants with Serum Metabolites |
264 | 1 | c 2014 |
338 | a print2 rdacarrier | |
500 | a De två sista författarna delar sistaförfattarskapet. | |
520 | a Objectives: Body mass index (BMI) is one of the most important risk factors for different metabolic and cardiovascular disorders. Previously, both genetic and environmental agents associated with BMI have been described. The main focus of this exploratory study was to find the circulating metabolites associated with BMI utilizing an untargeted metabolomics approach. Additionally, significant metabolites identified were studied for their relation with BMIassociated single nucleotide polymorphisms (SNPs). Materials and Methods: A total of 971 individuals from the Cancer of the Prostate in Sweden study (discovery sample- 275 prostate cancers patients and 182 controls; replication sample- 514 prostate cancer patients) were utilized. Blood samples were collected and serum metabolic profiling was obtained using ultra-performance liquid chromatography followed by mass spectrometry. Genotyping data was available for 26 out of 32 SNPs (21 genotyped and 5 proxies) previously robustly associated with BMI in individuals of European descent. Weighted genetic risk score was generated using these SNPs and studied for its association with metabolites. Results: A total of 6138 and 5209 metabolite features were detected in discovery and replication samples, respectively. Out of 6138 metabolite features in discovery sample, 201 were found to be significantly associated with BMI (p<8.15*10-6) after multiple testing correction. These 201 features were further investigated in the replication samples and 16 were found to be significantly associated with BMI (p<2.49*10-4). Seven of these significant features were isotopes for four of the primary metabolites. Four metabolites were putatively identified: monoacylglyceride (18:1), diacylglyrcerol (32:1) and two phosphatidylcholines (34:0 and 36:0). Weighted genetic score of BMI-associated SNPs was not associated with these four metabolites. Conclusion: Four identifiable metabolites (monoacylglyceride, diacyclglyrcerol and two phosphatidylcholines) were found to be significantly associated with BMI in both discovery and replication samples. Common variants associated with BMI did not show association with these four metabolites. - See more at: http://www.eurekaselect.com/120422/article#sthash.PgqffHqv.dpuf | |
653 | a Body mass index | |
653 | a genetic risk score | |
653 | a ultra-performance liquid chromatography | |
653 | a untargeted metabolomics | |
700 | 1 | a Karlsson, Robert4 aut |
700 | 1 | a Broeckling, Corey D.4 aut |
700 | 1 | a Hong, Mun-Gwan4 aut |
700 | 1 | a Prince, Jonathan A.4 aut |
700 | 1 | a Prenni, Jessica E.4 aut |
700 | 1 | a Ingelsson, Eriku Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epodemiologi4 aut0 (Swepub:uu)ering425 |
700 | 1 | a Wiklund, Fredrik4 aut |
710 | 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 org |
773 | 0 | t Current Metabolomicsg 2:1, s. 27-36-q 2:1<27-36-x 2213-235X |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-274647 |
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