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Mapping cis- and tr...
Mapping cis- and trans-regulatory effects across multiple tissues in twins.
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Grundberg, Elin (author)
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Small, Kerrin S (author)
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Hedman, Åsa K (author)
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show more...
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Nica, Alexandra C (author)
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Buil, Alfonso (author)
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Keildson, Sarah (author)
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Bell, Jordana T (author)
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Yang, Tsun-Po (author)
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Meduri, Eshwar (author)
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Barrett, Amy (author)
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Nisbett, James (author)
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Sekowska, Magdalena (author)
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Wilk, Alicja (author)
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Shin, So-Youn (author)
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Glass, Daniel (author)
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Travers, Mary (author)
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Min, Josine L (author)
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Ring, Sue (author)
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Ho, Karen (author)
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Thorleifsson, Gudmar (author)
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Kong, Augustine (author)
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Thorsteindottir, Unnur (author)
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Ainali, Chrysanthi (author)
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Dimas, Antigone S (author)
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Hassanali, Neelam (author)
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Ingle, Catherine (author)
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Knowles, David (author)
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Krestyaninova, Maria (author)
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Lowe, Christopher E (author)
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Di Meglio, Paola (author)
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Montgomery, Stephen B (author)
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Parts, Leopold (author)
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Potter, Simon (author)
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Surdulescu, Gabriela (author)
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Tsaprouni, Loukia (author)
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Tsoka, Sophia (author)
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Bataille, Veronique (author)
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Durbin, Richard (author)
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Nestle, Frank O (author)
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O'Rahilly, Stephen (author)
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Soranzo, Nicole (author)
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Lindgren, Cecilia M (author)
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Zondervan, Krina T (author)
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Ahmadi, Kourosh R (author)
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Schadt, Eric E (author)
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Stefansson, Kari (author)
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Smith, George Davey (author)
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McCarthy, Mark I (author)
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Deloukas, Panos (author)
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Dermitzakis, Emmanouil T (author)
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Spector, Tim D (author)
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- 2012-09-02
- 2012
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:10
- Related links:
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https://archive-ouve...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Sequence-based variation in gene expression is a key driver of disease risk. Common variants regulating expression in cis have been mapped in many expression quantitative trait locus (eQTL) studies, typically in single tissues from unrelated individuals. Here, we present a comprehensive analysis of gene expression across multiple tissues conducted in a large set of mono- and dizygotic twins that allows systematic dissection of genetic (cis and trans) and non-genetic effects on gene expression. Using identity-by-descent estimates, we show that at least 40% of the total heritable cis effect on expression cannot be accounted for by common cis variants, a finding that reveals the contribution of low-frequency and rare regulatory variants with respect to both transcriptional regulation and complex trait susceptibility. We show that a substantial proportion of gene expression heritability is trans to the structural gene, and we identify several replicating trans variants that act predominantly in a tissue-restricted manner and may regulate the transcription of many genes.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Grundberg, Elin
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Small, Kerrin S
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Hedman, Åsa K
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Nica, Alexandra ...
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Buil, Alfonso
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Keildson, Sarah
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show more...
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Bell, Jordana T
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Yang, Tsun-Po
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Meduri, Eshwar
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Barrett, Amy
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Nisbett, James
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Sekowska, Magdal ...
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Wilk, Alicja
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Shin, So-Youn
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Glass, Daniel
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Travers, Mary
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Min, Josine L
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Ring, Sue
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Ho, Karen
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Thorleifsson, Gu ...
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Kong, Augustine
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Thorsteindottir, ...
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Ainali, Chrysant ...
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Dimas, Antigone ...
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Hassanali, Neela ...
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Ingle, Catherine
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Knowles, David
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Krestyaninova, M ...
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Lowe, Christophe ...
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Di Meglio, Paola
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Montgomery, Step ...
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Parts, Leopold
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Potter, Simon
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Surdulescu, Gabr ...
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Tsaprouni, Louki ...
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Tsoka, Sophia
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Bataille, Veroni ...
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Durbin, Richard
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Nestle, Frank O
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O'Rahilly, Steph ...
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Soranzo, Nicole
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Lindgren, Cecili ...
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Zondervan, Krina ...
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Ahmadi, Kourosh ...
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Schadt, Eric E
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Stefansson, Kari
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Smith, George Da ...
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McCarthy, Mark I
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Deloukas, Panos
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Dermitzakis, Emm ...
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Spector, Tim D
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University