Sökning: onr:"swepub:oai:DiVA.org:uu-282365" > Neonatal exposure t...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03624naa a2200397 4500 | |
001 | oai:DiVA.org:uu-282365 | |
003 | SwePub | |
008 | 160405s2016 | |||||||||||000 ||eng| | |
009 | oai:slubar.slu.se:82829 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2823652 URI |
024 | 7 | a https://doi.org/10.1016/j.bbr.2016.02.0082 DOI |
024 | 7 | a https://res.slu.se/id/publ/828292 URI |
040 | a (SwePub)uud (SwePub)slu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Eriksson, Peru Uppsala universitet,Miljötoxikologi4 aut0 (Swepub:uu)pereriks |
245 | 1 0 | a Neonatal exposure to whole body ionizing radiation induces adult neurobehavioural defects :b Critical period, dose-response effects and strain and sex comparison |
264 | 1 | b Elsevier BV,c 2016 |
338 | a print2 rdacarrier | |
520 | a Development of the brain includes periods which can be critical for its normal maturation. The present study investigates specifically vulnerable peri-/postnatal periods in mice which are essential for understanding the etiology behind radiation induced neurotoxicity and functional defects, including evaluation of neurotoxicity between sexes or commonly used laboratory mouse strains following low/moderate doses of ionizing radiation (IR). Male Naval Medical Research Institute (NMRI) mice, whole body irradiated to a single 500 mGy IR dose, on postnatal day (PND) 3 or PND 10 showed an altered adult spontaneous behaviour and impaired habituation capacity, whereas irradiation on PND 19 did not have any impact on the studied variables. Both NMRI and C57bl/6 male and female mice showed an altered adult spontaneous behaviour and impaired habituation following a single whole body irradiation of 500 or 1000 mGy, but not after 20 or 100 mGy, on PND 10. The present study shows that exposure to low/moderate doses of IR during critical life stages might be involved in the induction of neurological/neurodegenerative disorder/disease. A specifically vulnerable period for radiation induced neurotoxicity seems to be around PND 3-10 in mice. Further studies are needed to investigate mechanisms involved in induction of developmental neurotoxicity following low dose irradiation. | |
650 | 7 | a NATURVETENSKAPx Biologix Utvecklingsbiologi0 (SwePub)106142 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Developmental Biology0 (SwePub)106142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Buratovic, Sonjau Uppsala universitet,Miljötoxikologi4 aut0 (Swepub:uu)sonbu412 |
700 | 1 | a Fredriksson, Andersu Uppsala universitet,Miljötoxikologi4 aut0 (Swepub:uu)andefred |
700 | 1 | a Stenerlöw, Bou Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)bostener |
700 | 1 | a Sundell-Bergman, Synnöveu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mark och miljö,Department of Soil and Environment4 aut0 (Swepub:slu)48101 |
710 | 2 | a Uppsala universitetb Miljötoxikologi4 org |
710 | 2 | a Sveriges lantbruksuniversitet |
773 | 0 | t Behavioural Brain Researchd : Elsevier BVg 304, s. 11-19q 304<11-19x 0166-4328x 1872-7549 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282365 |
856 | 4 8 | u https://doi.org/10.1016/j.bbr.2016.02.008 |
856 | 4 8 | u https://res.slu.se/id/publ/82829 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.