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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005299naa a2200553 4500
001oai:DiVA.org:uu-319543
003SwePub
008170406s2017 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:5273f7bc-8585-42e3-97a4-8610ea7c1e14
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3195432 URI
0247 a https://doi.org/10.1016/j.colsurfb.2016.12.0052 DOI
0247 a https://lup.lub.lu.se/record/5273f7bc-8585-42e3-97a4-8610ea7c1e142 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Luchini, Alessandrau Univ Napoli Federico 11, Dipartimento Sci Chim, Complesso Univ Monte S Angelo,Via Cintia, I-80126 Naples, Italy.;CSGI Consorzio Interuniv Sviluppo Sistemi Grande, Sesto Fiorentino, Italy.;Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin,University of Naples Federico II4 aut
2451 0a Neutron Reflectometry reveals the interaction between functionalized SPIONs and the surface of lipid bilayers
264 1b ELSEVIER SCIENCE BV,c 2017
338 a print2 rdacarrier
520 a The safe application of nanotechnology devices in biomedicine requires fundamental understanding on how they interact with and affect the different components of biological systems. In this respect, the cellular membrane, the cell envelope, certainly represents an important target or barrier for nanosystems. Here we report on the interaction between functionalized SuperParamagnetic Iron Oxide Nanoparticles (SPIONs), promising contrast agents for Magnetic Resonance Imaging (MRI), and lipid bilayers that mimic the plasma membrane. Neutron Reflectometry, supported by Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) experiments, was used to characterize this interaction by varying both SPION coating and lipid bilayer composition. In particular, the interaction of two different SPIONs, functionalized with a cationic surfactant and a zwitterionic phospholipid, and lipid bilayers, containing different amount of cholesterol, were compared. The obtained results were further validated by Dynamic Light Scattering (DLS) measurements and Cryogenic Transmission Electron Microscopy (Cryo-TEM) images. None of the investigated functionalized SPIONs were found to disrupt the lipid membrane. However, in all case we observed the attachment of the functionalized SPIONs onto the surface of the bilayers, which was affected by the bilayer rigidity, i.e. the cholesterol concentration.
650 7a NATURVETENSKAPx Biologix Biofysik0 (SwePub)106032 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biophysics0 (SwePub)106032 hsv//eng
650 7a NATURVETENSKAPx Kemix Fysikalisk kemi0 (SwePub)104022 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Physical Chemistry0 (SwePub)104022 hsv//eng
653 a SuperParamagnetic Iron Oxide
653 a Nanoparticles (SPIONs)
653 a Lysophosphatidylcholine
653 a Supported lipid bilayers
653 a Cholesterol
653 a Neutron reflectometry
653 a Cholesterol
653 a Lysophosphatidylcholine
653 a Neutron reflectometry
653 a SuperParamagnetic Iron Oxide Nanoparticles (SPIONs)
653 a Supported lipid bilayers
7001 a Gerelli, Yuriu Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin4 aut
7001 a Fragneto, Giovannau Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin4 aut
7001 a Nylander, Tommyu Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)fk1-tny
7001 a Pálsson, Gunnar K.u Uppsala University,Uppsala universitet,Materialfysik,Inst Laue Langevin, 71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin4 aut0 (Swepub:uu)gukpa839
7001 a Appavou, Marie-Sousaiu Garching Forschungszentrum, Julich Ctr Neutron Sci, Lichtenbergstr 1, D-85747 Garching, Germany.,Jülich Research Centre4 aut
7001 a Paduano, Luigiu Univ Napoli Federico 11, Dipartimento Sci Chim, Complesso Univ Monte S Angelo,Via Cintia, I-80126 Naples, Italy.;CSGI Consorzio Interuniv Sviluppo Sistemi Grande, Sesto Fiorentino, Italy.,University of Naples Federico II4 aut
7102 a Univ Napoli Federico 11, Dipartimento Sci Chim, Complesso Univ Monte S Angelo,Via Cintia, I-80126 Naples, Italy.;CSGI Consorzio Interuniv Sviluppo Sistemi Grande, Sesto Fiorentino, Italy.;Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.b Institut Laue Langevin4 org
7730 t Colloids and Surfaces Bd : ELSEVIER SCIENCE BVg 151, s. 76-87q 151<76-87x 0927-7765x 1873-4367
8564 u http://dx.doi.org/10.1016/j.colsurfb.2016.12.005y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-319543
8564 8u https://doi.org/10.1016/j.colsurfb.2016.12.005
8564 8u https://lup.lub.lu.se/record/5273f7bc-8585-42e3-97a4-8610ea7c1e14

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