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Sökning: onr:"swepub:oai:DiVA.org:uu-337796" > Changes in arterial...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004872naa a2200541 4500
001oai:DiVA.org:uu-337796
003SwePub
008180104s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:137948159
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3377962 URI
0247 a https://doi.org/10.1007/s00467-017-3848-42 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1379481592 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Al-Mashhadi, Ammar Nadhom Farmanu Uppsala universitet,Barnkirurgi4 aut0 (Swepub:uu)ammal264
2451 0a Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children
264 c 2017-12-01
264 1b Springer,c 2018
338 a electronic2 rdacarrier
520 a Objective Recent clinical studies have suggested an increased risk of elevated arterial pressure in patients with hydronephrosis. Animals with experimentally induced hydronephrosis develop hypertension, which is correlated to the degree of obstruction and increased oxidative stress. In this prospective study we investigated changes in arterial pressure, oxidative stress, and nitric oxide (NO) homeostasis following correction of hydronephrosis.Methods Ambulatory arterial pressure (24 h) was monitored in pediatric patients with hydronephrosis (n = 15) before and after surgical correction, and the measurements were compared with arterial pressure measurements in two control groups, i.e. healthy controls (n = 8) and operated controls (n = 8). Markers of oxidative stress and NO homeostasis were analyzed in matched urine and plasma samples.Results The preoperative mean arterial pressure was significantly higher in hydronephrotic patients [83 mmHg; 95% confidence interval (CI) 80–88 mmHg] than in healthy controls (74 mmHg; 95% CI 68–80 mmHg; p < 0.05), and surgical correction of ureteral obstruction reduced arterial pressure (76 mmHg; 95% CI 74–79 mmHg; p < 0.05). Markers of oxidative stress (i.e., 11- dehydroTXB2, PGF2α, 8-iso-PGF2α, 8,12-iso-iPF2α-VI) were significantly increased (p < 0.05) in patients with hydronephrosis compared with both control groups, and these were reduced following surgery (p < 0.05). Interestingly, there was a trend for increased NO synthase activity and signaling in hydronephrosis, which may indicate compensatory mechanism(s).Conclusion This study demonstrates increased arterial pressure and oxidative stress in children with hydronephrosis compared with healthy controls, which can be restored to normal levels by surgical correction of the obstruction. Once reference data on ambulatory blood pressure in this young age group become available, we hope cut-off values can be defined for deciding whether or not to correct hydronephrosis surgically.Keywords Blood pressure . Hydronephrosis . Hypertension . Nitric oxide . Oxidative stress . Ureteral obstruction 
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a Blood pressure
653 a Hydronephrosis
653 a Hypertension
653 a Nitric oxide
653 a Oxidative stress
653 a Ureteral obstruction
7001 a Checa, Antoniou Karolinska Institutet4 aut
7001 a Wåhlin, Nilsu Karolinska Institute4 aut
7001 a Nevéus, Tryggve,d 1965-u Uppsala universitet,Pediatrisk inflammationsforskning4 aut0 (Swepub:uu)trygneve
7001 a Fossum, Magdalenau Karolinska Institutet4 aut
7001 a Wheelock, Craig E.u Karolinska Institutet4 aut
7001 a Karanikas, Birgittau Uppsala universitet,Barnkirurgi4 aut
7001 a Stenberg, Arneu Uppsala universitet,Barnkirurgi4 aut0 (Swepub:uu)arnesten
7001 a Persson, A. Erik G.u Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)erikpers
7001 a Carlström, Mattiasu Karolinska Institutet4 aut
7102 a Uppsala universitetb Barnkirurgi4 org
7730 t Pediatric nephrology (Berlin, West)d : Springerg 33:4, s. 639-649q 33:4<639-649x 0931-041Xx 1432-198X
8564 u https://doi.org/10.1007/s00467-017-3848-4y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1170902/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://link.springer.com/content/pdf/10.1007/s00467-017-3848-4.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-337796
8564 8u https://doi.org/10.1007/s00467-017-3848-4
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:137948159

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