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FältnamnIndikatorerMetadata
00006909naa a2200733 4500
001oai:DiVA.org:uu-351263
003SwePub
008180611s2018 | |||||||||||000 ||eng|
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009oai:prod.swepub.kib.ki.se:137801075
009oai:DiVA.org:liu-144030
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3512632 URI
0247 a https://doi.org/10.1007/s00198-017-4325-42 DOI
0247 a https://lup.lub.lu.se/record/0d1afe71-0222-4dc0-8800-915a51ec83de2 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1378010752 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1440302 URI
040 a (SwePub)uud (SwePub)lud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Jonsson, E.u Quantify Res, Hantverkargatan 8, SE-11221 Stockholm, Sweden.,Quantify Research AB,Quantify Research, Stockholm, Sweden4 aut
2451 0a A health economic simulation model for the clinical management of osteoporosis
264 c 2017-12-01
264 1b Springer Science and Business Media LLC,c 2018
338 a print2 rdacarrier
500 a Funding agencies:  Medtronic
520 a The objective was to estimate the burden of osteoporosis in Sweden based on current clinical practice and the cost-effectiveness of improvements in the management of osteoporosis over the clinical management compared to current clinical practice. Results showed that better compliance to treatment guidelines is associated with better projected outcomes and cost-savings.IntroductionThe purpose of this study is to estimate the burden of osteoporosis in Sweden based on current clinical practice and the cost-effectiveness of improvements in the management of osteoporosis over the clinical management compared to current clinical practice.MethodsThe analysis was carried out using a model that simulates the individual patients considered for pharmacological treatment during 1 year and their projected osteoporosis treatment pathway, quality-adjusted life years (QALYs) and costs over their remaining lifetime. All patients regardless of treatment or no treatment were simulated. Information on current management of osteoporosis in terms of patient characteristics and treatment patterns were derived from a Swedish osteoporosis research database based on national registers and patient records. Current (standard) clinical management was compared with alternative scenarios mirroring Swedish treatment guidelines.ResultsThe national burden in terms of lost QALYs was estimated at 14,993 QALYs and the total economic cost at €776M. Scenario analyses showed that 382–3864 QALYs could be gained at a cost/QALY ranging from cost-saving to €31368, depending on the scenario. The margin of investment, i.e. the maximum amount that could be invested in the healthcare system to achieve these improvements up to the limit of the willingness to pay/QALY, was estimated at €199M on a population level (€3,634/patient).ConclusionsThe analysis showed that better compliance to treatment guidelines is associated with better projected outcomes and cost-savings. From a cost-effectiveness perspective, there is also considerable room for investment to achieve these improvements in the management of osteoporosis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi0 (SwePub)303012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Health Care Service and Management, Health Policy and Services and Health Economy0 (SwePub)303012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Cost
653 a Fracture
653 a Osteoporosis
653 a Quality-of-life
653 a Register
653 a Sweden
653 a Cost
653 a Fracture
653 a Osteoporosis
653 a Quality-of-life
653 a Register
653 a Sweden
7001 a Hansson-Hedblom, A.u Quantify Res, Hantverkargatan 8, SE-11221 Stockholm, Sweden.,Quantify Research AB,Quantify Research, Stockholm, Sweden4 aut
7001 a Ljunggren, Östenu Uppsala universitet,Endokrinologi och mineralmetabolism,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)osteljun
7001 a Åkesson, K.u Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,University of Sheffield, Sheffield, UK; Catholic University of Australia, Melbourne, Australia,Australian Catholic University,Department of Clinical Sciences, Clinical and Molecular Osteoporosis Unit, Lund University, Malmö, Sweden4 aut0 (Swepub:lu)orto-kak
7001 a Spångeus, Anna,d 1975-u Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken4 aut0 (Swepub:liu)annsp18
7001 a Kanis, J. A.u Univ Sheffield, Sheffield, S Yorkshire, England.;Catholic Univ Australia, Melbourne, Vic, Australia.4 aut
7001 a Borgstrom, F.u Karolinska Institutet,Karolinska Institute,Quantify Research AB,Quantify Research, Stockholm; Karolinska Institutet, Stockholm, Sweden4 aut
7102 a Quantify Res, Hantverkargatan 8, SE-11221 Stockholm, Sweden.b Quantify Research AB4 org
7730 t Osteoporosis Internationald : Springer Science and Business Media LLCg 29:3, s. 545-555q 29:3<545-555x 0937-941Xx 1433-2965
8564 u http://liu.diva-portal.org/smash/get/diva2:1170625/FULLTEXT01
8564 u http://dx.doi.org/10.1007/s00198-017-4325-4y FULLTEXT
8564 u https://liu.diva-portal.org/smash/get/diva2:1170625/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-351263
8564 8u https://doi.org/10.1007/s00198-017-4325-4
8564 8u https://lup.lub.lu.se/record/0d1afe71-0222-4dc0-8800-915a51ec83de
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:137801075
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144030

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