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Sökning: onr:"swepub:oai:DiVA.org:uu-353183" > Synthesis, Antibact...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003578naa a2200457 4500
001oai:DiVA.org:uu-353183
003SwePub
008180618s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3531832 URI
0247 a https://doi.org/10.1134/S10703632180302462 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Saeed, A.u Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan4 aut
2451 0a Synthesis, Antibacterial and Antileishmanial Activity, Cytotoxicity, and Molecular Docking of New Heteroleptic Copper(I) Complexes with Thiourea Ligands and Triphenylphosphine
264 1b MAIK NAUKA/INTERPERIODICA/SPRINGER,c 2018
338 a print2 rdacarrier
520 a A series of copper(I) complexes with triphenylphosphine and N-acyl-N'-arylthioureas were synthesized and characterized by elemental analysis and IR and NMR (H-1, C-13, P-31) spectroscopy. The thiourea ligands and their copper(I) triphenylphosphine complexes were screened for antibacterial and antileishmanial activities and cytotoxicity. The synthesized compounds showed much better activity as compared to glucantime and Kanamycin used as reference drugs. The thiourea ligands showed better activity than their Cu(I) complexes. The molecular docking technique was utilized to ascertain the mechanism of action toward molecular targets (GP63 and 16S-rRNA A-site). It was found that the ligands and complexes were stabilized at the active site by electrostatic and hydrophobic forces, consistent with the corresponding experimental results. The in silico study of the binding pattern predicted that one of the synthesized ligands, N-(5-chloro-2-nitrophenyl)-N'-pentanoylthiourea, can serve as a potential surrogate for hit-to-lead generation and design of novel antibacterial and antileishmanial agents.
650 7a NATURVETENSKAPx Kemix Organisk kemi0 (SwePub)104052 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Organic Chemistry0 (SwePub)104052 hsv//eng
653 a thiourea
653 a copper(I) complexes
653 a triphenylphosphine
653 a molecular docking
653 a cytotoxicity
653 a antileishmanial activity
653 a antibacterial activity
7001 a Larik, F. A.u Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan4 aut
7001 a Jabeen, F.u Laurentian Univ, Cardiovasc & Metab Res Unit, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada4 aut
7001 a Mehfooz, H.u Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan4 aut
7001 a Ghumro, S. A.u Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan4 aut
7001 a El-Seedi, Hesham R.u Uppsala universitet,Farmakognosi4 aut0 (Swepub:uu)heels173
7001 a Ali, M.u Quaid I Azam Univ, Dept Biol Sci, Islamabad 45320, Pakistan4 aut
7001 a Channar, P. A.u Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan4 aut
7001 a Ashraf, H.u Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan4 aut
7102 a Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistanb Laurentian Univ, Cardiovasc & Metab Res Unit, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada4 org
7730 t Russian journal of general chemistryd : MAIK NAUKA/INTERPERIODICA/SPRINGERg 88:3, s. 541-550q 88:3<541-550x 1070-3632x 1608-3350
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-353183
8564 8u https://doi.org/10.1134/S1070363218030246

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