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Sökning: onr:"swepub:oai:DiVA.org:uu-357270" > Adjusted Troponin I...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006474naa a2200541 4500
001oai:DiVA.org:uu-357270
003SwePub
008180817s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3572702 URI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Boeckel, Jes-Nielsu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany;Univ Hosp Leipzig, Dept Internal Med, Cardiol, Leipzig, Germany4 aut
2451 0a Adjusted Troponin I for Improved Evaluation of Patients with Chest Pain
264 1b NATURE PUBLISHING GROUP,c 2018
338 a electronic2 rdacarrier
520 a The use of cardiac troponins (cTn) is the gold standard for diagnosing myocardial infarction. Independent of myocardial infarction (MI), however, sex, age and kidney function affect cTn levels. Here we developed a method to adjust cTnI levels for age, sex, and renal function, maintaining a unified cut-off value such as the 99th percentile. A total of 4587 individuals enrolled in a prospective longitudinal study were used to develop a model for adjustment of cTn. cTnI levels correlated with age and estimated glomerular filtration rate (eGFR) in males/females with r(age) = 0.436/0.518 and with (r)(eGFR) = -0.142/-0.207. For adjustment, these variables served as covariates in a linear regression model with cTnl as dependent variable. This adjustment model was then applied to a real-world cohort of 1789 patients with suspected acute MI (AMI) (N = 407). Adjusting cTnI showed no relevant loss of diagnostic information, as evidenced by comparable areas under the receiver operator characteristic curves, to identify AMI in males and females for adjusted and unadjusted cTnI. In specific patients groups such as in elderly females, adjusting cTnI improved specificity for AMI compared with unadjusted cTnI. Specificity was also improved in patients with renal dysfunction by using the adjusted cTnI values. Thus, the adjustments improved the diagnostic ability of cTnI to identify AMI in elderly patients and in patients with renal dysfunction. Interpretation of cTnI values in complex emergency cases is facilitated by our method, which maintains a single diagnostic cut-off value in all patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Palapies, Larsu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany4 aut
7001 a Klotsche, Jensu Tech Univ Dresden, Clin Psychol & Psychotherapy, Dresden, Germany4 aut
7001 a Zeller, Tanjau German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany4 aut
7001 a von Jeinsen, Beatriceu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany4 aut
7001 a Perret, Maya F.u Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany4 aut
7001 a Kleinhaus, Soeren L.u Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany4 aut
7001 a Pieper, Larsu Tech Univ Dresden, Clin Psychol & Psychotherapy, Dresden, Germany4 aut
7001 a Tzikas, Stergiosu Aristotle Univ Thessaloniki, Ippokrateio Hosp, Dept Cardiol 3, Thessaloniki, Greece;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 2, Mainz, Germany4 aut
7001 a Leistner, Davidu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany4 aut
7001 a Bickel, Christophu Fed Armed Forces Hosp, Dept Internal Med, Koblenz, Germany4 aut
7001 a Stalla, Guenter K.u Max Planck Inst Psychiat, Neuroendocrinol, Munich, Germany4 aut
7001 a Lehnert, Hendriku Univ Hosp Schleswig Holstein, Dept Internal Med 1, Lubeck, Germany4 aut
7001 a Lindahl, Bertil,d 1957-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)belin227
7001 a Wittchen, Hans-Ulrichu Tech Univ Dresden, Clin Psychol & Psychotherapy, Dresden, Germany4 aut
7001 a Silber, Sigmundu Praxisklin, Kardiol Gemeinschaftspraxis, Munich, Germany4 aut
7001 a Baldus, Stephanu Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany;Univ Cologne, Heart Ctr, Cologne, Germany4 aut
7001 a Maerz, Winfriedu Synlab Serv GmbH, Synlab Akad Arztl Fortbildung, Mannheim, Germany4 aut
7001 a Dimmeler, Stefanieu German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany4 aut
7001 a Blankenberg, Stefanu German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany4 aut
7001 a Muenzel, Thomasu German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 2, Mainz, Germany4 aut
7001 a Zeiher, Andreas M.u Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany4 aut
7001 a Keller, Tillu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Kerckhoff Heart & Thorax Ctr, Bad Nauheim, Germany4 aut
7102 a Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany;Univ Hosp Leipzig, Dept Internal Med, Cardiol, Leipzig, Germanyb Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany4 org
7730 t Scientific Reportsd : NATURE PUBLISHING GROUPg 8q 8x 2045-2322
8564 u https://doi.org/10.1038/s41598-018-26120-ly Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1239735/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-357270

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